5G55

3-Quinoline Carboxamides inhibitors of Pi3K

Summary for 5G55

• Entry DOI: 10.2210/pdb5g55/pdb
• Descriptor: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 6-cyano-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]quinoline-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase, atm
• Biological source: HOMO SAPIENS
• Total number of polymer chains: 1
• Total formula weight: 111182.61

Authors

Edman, K.,Phillips, C. (deposition date: 2016-05-20, release date: 2016-08-03, Last modification date: 2018-11-14)

• Primary citation: Degorce, S.L.,Barlaam, B.,Cadogan, E.,Dishington, A.P.,Ducray, R.,Glossop, S.C.,Hassall, L.A.,Lach, F.,Lau, A.,Mcguire, T.M.,Nowak, T.,Ouvry, G.,Pike, K.G.,Thomason, A.G.; Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (Atm) Kinase.; J.Med.Chem., 59:6281-, 2016; PubMed: 27259031; DOI: 10.1021/ACS.JMEDCHEM.6B00519

Experimental method

X-RAY DIFFRACTION (2.45 Å)