5W10
 
 | | Lcd1 GAF domain in complex with cAMP ligand | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cGMP-specific phosphodiesterase | | 著者 | Guzzo, C.R, Maciel, N.K, Barbosa, A.S, Farah, C.S. | | 登録日 | 2017-06-01 | | 公開日 | 2017-06-28 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural and Enzymatic Characterization of a cAMP-Dependent Diguanylate Cyclase from Pathogenic Leptospira Species.
J. Mol. Biol., 429, 2017
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1J59
 | | CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | 分子名称: | 5'-D(*AP*TP*AP*TP*GP*TP*CP*AP*CP*AP*CP*TP*TP*TP*TP*CP*G )-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*GP*TP*GP*TP*GP*AP*C)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Parkinson, G, Wilson, C, Gunasekera, A, Ebright, Y.W, Ebright, R.H, Berman, H.M. | | 登録日 | 2002-03-01 | | 公開日 | 2002-03-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface.
J.Mol.Biol., 260, 1996
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5BTX
 | | Structure of the N-terminal domain of lpg1496 from Legionella pneumophila in complex with nucleotide | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, lpg1496 | | 著者 | Wong, K, Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | 登録日 | 2015-06-03 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism.
J.Biol.Chem., 290, 2015
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4QX5
 | | Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1 | | 著者 | Huang, G.Y, Gerlits, O.O, Blakeley, M.P, Sankaran, B, Kovalevsky, A.Y, Kim, C. | | 登録日 | 2014-07-18 | | 公開日 | 2014-11-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.318 Å) | | 主引用文献 | Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Biochemistry, 53, 2014
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3N4M
 | | E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Lara-Gonzalez, S, Birktoft, J.J, Lawson, C.L. | | 登録日 | 2010-05-21 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.987 Å) | | 主引用文献 | The RNA Polymerase alpha Subunit Recognizes the DNA Shape of the Upstream Promoter Element.
Biochemistry, 59, 2020
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6B6H
 | | The cryo-EM structure of a bacterial class I transcription activation complex | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. | | 登録日 | 2017-10-02 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of bacterial transcription activation.
Science, 358, 2017
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2PW3
 | | Structure of the PDE4D-cAMP complex | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | | 著者 | Wang, H, Robinson, H, Ke, H. | | 登録日 | 2007-05-10 | | 公開日 | 2007-10-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.
J.Mol.Biol., 371, 2007
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4CLT
 | | Crystal structure of human soluble Adenylyl Cyclase with adenosine-3', 5'-cyclic-monophosphate and pyrophosphate | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... | | 著者 | Kleinboelting, S, Weyand, M, Steegborn, C. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLP
 | | Crystal structure of human soluble Adenylyl Cyclase complex with adenosine-3',5'-cyclic-monophosphate | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Kleinboelting, S, Weyand, M, Steegborn, C. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1RUN
 | | CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*TP*CP*G )-3'), DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), ... | | 著者 | Parkinson, G.N, Gunasekera, A, Vojtechovsky, J, Zhang, X, Kunkel, T.A, Berman, H.M, Ebright, R.H. | | 登録日 | 1996-05-26 | | 公開日 | 1997-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Aromatic hydrogen bond in sequence-specific protein DNA recognition.
Nat.Struct.Biol., 3, 1996
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1RUO
 | | CATABOLITE GENE ACTIVATOR PROTEIN (CAP) MUTANT/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*TP*CP*G )-3'), DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), ... | | 著者 | Parkinson, G.N, Ebright, R.H, Berman, H.M. | | 登録日 | 1996-05-26 | | 公開日 | 1997-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Aromatic hydrogen bond in sequence-specific protein DNA recognition.
Nat.Struct.Biol., 3, 1996
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6M63
 | | Crystal structure of a cAMP sensor G-Flamp1. | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein | | 著者 | Zhou, Z, Chen, S, Wang, L, Chu, J. | | 登録日 | 2020-03-12 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.
Nat Commun, 13, 2022
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6GPO
 | | Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with cAMP | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | 著者 | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | | 登録日 | 2018-06-06 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
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6GPR
 | | Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with cAMP | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Heat shock protein HSP 90-alpha | | 著者 | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | | 登録日 | 2018-06-06 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
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6H7E
 | | GEF regulatory domain | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ... | | 著者 | Ferrandez, Y, Cherfils, J, Peurois, F. | | 登録日 | 2018-07-31 | | 公開日 | 2020-02-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
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6GQU
 | | Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with cAMP | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Heat shock protein HSP 90-alpha | | 著者 | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | | 登録日 | 2018-06-08 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
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3IYD
 | | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, DNA (98-MER), ... | | 著者 | Hudson, B.P, Quispe, J, Lara, S, Kim, Y, Berman, H, Arnold, E, Ebright, R.H, Lawson, C.L. | | 登録日 | 2009-08-01 | | 公開日 | 2009-11-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (19.799999 Å) | | 主引用文献 | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
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3KCC
 | | Crystal structure of D138L mutant of Catabolite Gene Activator Protein | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | | 著者 | Tao, W.B, Gao, Z.Q, Zhou, J.H, Dong, Y.H, Yu, S.N. | | 登録日 | 2009-10-21 | | 公開日 | 2009-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | The 1.6A resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer
Int.J.Biol.Macromol., 48, 2011
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1LB2
 | | Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA | | 分子名称: | 5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*AP*GP*GP*AP*AP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*TP*TP*CP*CP*TP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Benoff, B, Yang, H, Lawson, C.L, Parkinson, G, Liu, J, Blatter, E, Ebright, Y.W, Berman, H.M, Ebright, R.H. | | 登録日 | 2002-04-01 | | 公開日 | 2002-09-06 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural basis of transcription activation: the CAP-alpha CTD-DNA complex.
Science, 297, 2002
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1O3R
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
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1O3Q
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
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1O3T
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*TP*CP*G)-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex:
DNA Binding Specificity Based on Energetics of DNA Kinking
J.Mol.Biol., 314, 2001
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4MX3
 | | Crystal Structure of PKA RIalpha Homodimer | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit | | 著者 | Bruystens, J.G.H, Wu, J, Fortezzo, A, Kornev, A.P, Blumenthal, D.A, Taylor, S.S. | | 登録日 | 2013-09-25 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.88 Å) | | 主引用文献 | PKA RI alpha Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease.
Structure, 22, 2014
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6ZQS
 | | Crystal structure of double-phosphorylated p38alpha with ATF2(83-102) | | 分子名称: | 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 14 | | 著者 | Kirsch, K, Sok, P, Poti, A.L, Remenyi, A. | | 登録日 | 2020-07-10 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Nat Commun, 11, 2020
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1O3S
 | | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | 著者 | Chen, S, Ebright, R.H, Berman, H.M. | | 登録日 | 2003-03-18 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: Alteration of DNA Binding Specificity Through Alteration of DNA Kinking
J.Mol.Biol., 314, 2001
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