7CCR

Structure of the 2:2 cGAS-nucleosome complex

Summary for 7CCR

• Entry DOI: 10.2210/pdb7ccr/pdb
• EMDB information: 30340
• Descriptor: Histone H3.1, Histone H4, Histone H2A type 1-B/E, ... (7 entities in total)
• Functional Keywords: cgas, nucleosome, inhibition, cryo-em, immune system, structural protein-transferase-dna complex, structural protein/transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 22
• Total formula weight: 435878.34

Authors

Cao, D.,Han, X.,Fan, X.,Xu, R.M.,Zhang, X. (deposition date: 2020-06-17, release date: 2020-10-07, Last modification date: 2024-03-27)

• Primary citation: Cao, D.,Han, X.,Fan, X.,Xu, R.M.,Zhang, X.; Structural basis for nucleosome-mediated inhibition of cGAS activity.; Cell Res., 30:1088-1097, 2020; PubMed: 33051594; DOI: 10.1038/s41422-020-00422-4

Experimental method

ELECTRON MICROSCOPY (4.9 Å)