5N6I
Crystal structure of mouse cGAS in complex with 39 bp DNA
Summary for 5N6I
Entry DOI | 10.2210/pdb5n6i/pdb |
Descriptor | Cyclic GMP-AMP synthase, DNA (37-MER), DNA (36-MER), ... (4 entities in total) |
Functional Keywords | nucleotidyltransferase, cyclic gmp-amp synthase, cgas, dna-binding, activator dna, pattern recognition receptor, innate immune response, viral dna recognition, transferase |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 14 |
Total formula weight | 356809.53 |
Authors | Andreeva, L.,Kostrewa, D.,Hopfner, K.-P. (deposition date: 2017-02-15, release date: 2017-09-13, Last modification date: 2024-01-17) |
Primary citation | Andreeva, L.,Hiller, B.,Kostrewa, D.,Lassig, C.,de Oliveira Mann, C.C.,Jan Drexler, D.,Maiser, A.,Gaidt, M.,Leonhardt, H.,Hornung, V.,Hopfner, K.P. cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature, 549:394-398, 2017 Cited by PubMed: 28902841DOI: 10.1038/nature23890 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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