5N6I
Crystal structure of mouse cGAS in complex with 39 bp DNA
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 601 |
Chain | Residue |
A | HIS378 |
A | CYS384 |
A | CYS385 |
A | CYS392 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 601 |
Chain | Residue |
B | HIS378 |
B | CYS384 |
B | CYS385 |
B | CYS392 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN C 601 |
Chain | Residue |
C | CYS384 |
C | CYS385 |
C | CYS392 |
C | HIS378 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN D 601 |
Chain | Residue |
D | HIS378 |
D | CYS384 |
D | CYS385 |
D | CYS392 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN E 601 |
Chain | Residue |
E | HIS378 |
E | CYS384 |
E | CYS385 |
E | CYS392 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN F 601 |
Chain | Residue |
F | HIS378 |
F | CYS384 |
F | CYS385 |
F | CYS392 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 48 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23647843 |
Chain | Residue | Details |
A | LYS402 | |
A | SER420 | |
B | THR197 | |
B | SER199 | |
B | GLU211 | |
B | ASP213 | |
B | ASP307 | |
B | GLU371 | |
B | LYS402 | |
B | SER420 | |
C | THR197 | |
C | SER199 | |
C | GLU211 | |
C | ASP213 | |
C | ASP307 | |
C | GLU371 | |
C | LYS402 | |
C | SER420 | |
D | THR197 | |
D | SER199 | |
D | GLU211 | |
D | ASP213 | |
D | ASP307 | |
D | GLU371 | |
D | LYS402 | |
D | SER420 | |
E | THR197 | |
E | SER199 | |
E | GLU211 | |
E | ASP213 | |
E | ASP307 | |
E | GLU371 | |
E | LYS402 | |
E | SER420 | |
F | THR197 | |
F | SER199 | |
F | GLU211 | |
F | ASP213 | |
F | ASP307 | |
F | GLU371 | |
F | LYS402 | |
F | SER420 | |
A | THR197 | |
A | SER199 | |
A | GLU211 | |
A | ASP213 | |
A | ASP307 | |
A | GLU371 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24332030, ECO:0007744|PDB:4LEZ |
Chain | Residue | Details |
C | GLY290 | |
C | LYS350 | |
C | ARG364 | |
D | GLY290 | |
D | LYS350 | |
D | ARG364 | |
E | GLY290 | |
E | LYS350 | |
E | ARG364 | |
F | GLY290 | |
F | LYS350 | |
F | ARG364 | |
A | GLY290 | |
A | LYS350 | |
A | ARG364 | |
B | GLY290 | |
B | LYS350 | |
B | ARG364 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6X59, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
Chain | Residue | Details |
A | HIS378 | |
A | CYS384 | |
B | HIS378 | |
B | CYS384 | |
C | HIS378 | |
C | CYS384 | |
D | HIS378 | |
D | CYS384 | |
E | HIS378 | |
E | CYS384 | |
F | HIS378 | |
F | CYS384 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6XJD, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
Chain | Residue | Details |
A | CYS385 | |
B | CYS385 | |
C | CYS385 | |
D | CYS385 | |
E | CYS385 | |
F | CYS385 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32911480, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000, ECO:0007744|PDB:5N6I, ECO:0007744|PDB:5XZB, ECO:0007744|PDB:5XZE, ECO:0007744|PDB:5XZG, ECO:0007744|PDB:6X5A, ECO:0007744|PDB:7BUJ, ECO:0007744|PDB:7BUM, ECO:0007744|PDB:7BUQ, ECO:0007744|PDB:7JO9, ECO:0007744|PDB:7JOA |
Chain | Residue | Details |
C | CYS392 | |
D | CYS392 | |
E | CYS392 | |
F | CYS392 | |
A | CYS392 | |
B | CYS392 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Arginine-anchor => ECO:0000269|PubMed:31808743, ECO:0000269|PubMed:32911480, ECO:0000269|PubMed:32911481, ECO:0000269|PubMed:32913000 |
Chain | Residue | Details |
C | ARG241 | |
D | ARG241 | |
E | ARG241 | |
F | ARG241 | |
A | ARG241 | |
B | ARG241 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | SITE: Cleavage; by CASP3 => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
C | ASP307 | |
D | ASP307 | |
E | ASP307 | |
F | ASP307 | |
A | ASP307 | |
B | ASP307 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:35460603 |
Chain | Residue | Details |
A | GLU176 | |
B | GLU176 | |
C | GLU176 | |
D | GLU176 | |
E | GLU176 | |
F | GLU176 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
A | SER199 | |
B | SER199 | |
C | SER199 | |
D | SER199 | |
E | SER199 | |
F | SER199 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
C | TYR201 | |
A | TYR201 | |
B | TYR201 | |
D | TYR201 | |
E | TYR201 | |
F | TYR201 |
site_id | SWS_FT_FI11 |
Number of Residues | 6 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:26829768 |
Chain | Residue | Details |
B | GLU272 | |
C | GLU272 | |
D | GLU272 | |
E | GLU272 | |
F | GLU272 | |
A | GLU272 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:32351706 |
Chain | Residue | Details |
A | SER291 | |
B | SER291 | |
C | SER291 | |
D | SER291 | |
E | SER291 | |
F | SER291 |
site_id | SWS_FT_FI13 |
Number of Residues | 6 |
Details | MOD_RES: 5-glutamyl glutamate => ECO:0000269|PubMed:26829768 |
Chain | Residue | Details |
A | GLU302 | |
B | GLU302 | |
C | GLU302 | |
D | GLU302 | |
E | GLU302 | |
F | GLU302 |
site_id | SWS_FT_FI14 |
Number of Residues | 18 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
C | LYS372 | |
C | LYS382 | |
C | LYS402 | |
D | LYS372 | |
D | LYS382 | |
D | LYS402 | |
E | LYS372 | |
E | LYS382 | |
E | LYS402 | |
F | LYS372 | |
F | LYS382 | |
F | LYS402 | |
A | LYS372 | |
A | LYS382 | |
A | LYS402 | |
B | LYS372 | |
B | LYS382 | |
B | LYS402 |
site_id | SWS_FT_FI15 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:32474700 |
Chain | Residue | Details |
A | SER420 | |
B | SER420 | |
C | SER420 | |
D | SER420 | |
E | SER420 | |
F | SER420 |
site_id | SWS_FT_FI16 |
Number of Residues | 6 |
Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:35210392 |
Chain | Residue | Details |
A | LYS491 | |
C | LYS491 | |
E | LYS491 | |
B | LYS491 | |
D | LYS491 | |
F | LYS491 |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
C | CYS392 | |
C | CYS393 | |
C | CYS459 | |
D | CYS392 | |
D | CYS393 | |
D | CYS459 | |
E | CYS392 | |
E | CYS393 | |
E | CYS459 | |
F | CYS392 | |
F | CYS393 | |
F | CYS459 | |
A | CYS392 | |
A | CYS393 | |
A | CYS459 | |
B | CYS392 | |
B | CYS393 | |
B | CYS459 |
site_id | SWS_FT_FI18 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
A | LYS217 | |
B | LYS217 | |
C | LYS217 | |
D | LYS217 | |
E | LYS217 | |
F | LYS217 |
site_id | SWS_FT_FI19 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27637147, ECO:0000269|PubMed:32457395 |
Chain | Residue | Details |
D | LYS464 | |
E | LYS464 | |
F | LYS464 | |
A | LYS464 | |
B | LYS464 | |
C | LYS464 |
site_id | SWS_FT_FI20 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27637147, ECO:0000269|PubMed:32457395 |
Chain | Residue | Details |
A | LYS271 | |
B | LYS271 | |
C | LYS271 | |
D | LYS271 | |
E | LYS271 | |
F | LYS271 |
site_id | SWS_FT_FI21 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:29426904 |
Chain | Residue | Details |
A | LYS335 | |
B | LYS335 | |
C | LYS335 | |
D | LYS335 | |
E | LYS335 | |
F | LYS335 |
site_id | SWS_FT_FI22 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
A | LYS372 | |
B | LYS372 | |
C | LYS372 | |
D | LYS372 | |
E | LYS372 | |
F | LYS372 |
site_id | SWS_FT_FI23 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:28095500 |
Chain | Residue | Details |
A | LYS382 | |
B | LYS382 | |
C | LYS382 | |
D | LYS382 | |
E | LYS382 | |
F | LYS382 |
site_id | SWS_FT_FI24 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8N884 |
Chain | Residue | Details |
D | LYS399 | |
D | LYS402 | |
E | LYS399 | |
E | LYS402 | |
F | LYS399 | |
F | LYS402 | |
A | LYS399 | |
A | LYS402 | |
B | LYS399 | |
B | LYS402 | |
C | LYS399 | |
C | LYS402 |