5N6I
Crystal structure of mouse cGAS in complex with 39 bp DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Cyclic GMP-AMP synthase | polymer | 370 | 43401.2 | 6 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (Mouse) | m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | G, I, K, M (G, I, K, M) | DNA (37-MER) | polymer | 39 | 11987.7 | 4 | synthetic construct | ||
| 3 | H, J, L, N (H, J, L, N) | DNA (36-MER) | polymer | 39 | 12014.8 | 4 | synthetic construct | ||
| 4 | O, P, Q, R, S... (A, B, C, D, E...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
A, B, C, D, E, F: 139 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Gly 138 | - | expression tag |
| Met 140 | Pro 140 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 356417.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 356809.5 |
