6CTA

Structure of the human cGAS-DNA complex with ATP

Summary for 6CTA

• Entry DOI: 10.2210/pdb6cta/pdb
• Descriptor: Cyclic GMP-AMP synthase, DNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*A)-3'), ... (7 entities in total)
• Functional Keywords: cgas, sting, innate immunity, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 53909.30

Authors

Zhou, W.,Whiteley, A.T.,de Oliveira Mann, C.C.,Morehouse, B.R.,Mekalanos, J.J.,Kranzusch, P.J. (deposition date: 2018-03-22, release date: 2018-07-18, Last modification date: 2023-10-04)

• Primary citation: Zhou, W.,Whiteley, A.T.,de Oliveira Mann, C.C.,Morehouse, B.R.,Nowak, R.P.,Fischer, E.S.,Gray, N.S.,Mekalanos, J.J.,Kranzusch, P.J.; Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.; Cell, 174:300-311.e11, 2018; PubMed: 30007416; DOI: 10.1016/j.cell.2018.06.026

Experimental method

X-RAY DIFFRACTION (2.779 Å)