8SLE
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![BU of 8sle by Molmil](/molmil-images/mine/8sle) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-3 | 分子名称: | Transient receptor potential cation channel subfamily M member 5 | 著者 | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | 登録日 | 2023-04-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SLC
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![BU of 8slc by Molmil](/molmil-images/mine/8slc) | High Affinity nanobodies against GFP | 分子名称: | CHLORIDE ION, GLYCEROL, Green fluorescent protein, ... | 著者 | Ketaren, N.E, Rout, M.P, Bonanno, J.B, Almo, S.C. | 登録日 | 2023-04-21 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | High Affinity nanobodies against GFP To Be Published
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8SLB
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![BU of 8slb by Molmil](/molmil-images/mine/8slb) | X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12 | 分子名称: | CHLORIDE ION, Cobalt/magnesium transport protein CorA, sAB C12 Heavy Chain, ... | 著者 | Dominik, P.K, Erramilli, S.K, Reddy, B.G, Kossiakoff, A.A. | 登録日 | 2023-04-21 | 公開日 | 2023-06-07 | 最終更新日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA. J.Mol.Biol., 435, 2023
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8SLA
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![BU of 8sla by Molmil](/molmil-images/mine/8sla) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-2 | 分子名称: | Transient receptor potential cation channel subfamily M member 5 | 著者 | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | 登録日 | 2023-04-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SL8
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![BU of 8sl8 by Molmil](/molmil-images/mine/8sl8) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-1 | 分子名称: | Transient receptor potential cation channel subfamily M member 5 | 著者 | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | 登録日 | 2023-04-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SL7
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![BU of 8sl7 by Molmil](/molmil-images/mine/8sl7) | |
8SL6
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![BU of 8sl6 by Molmil](/molmil-images/mine/8sl6) | |
8SL0
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![BU of 8sl0 by Molmil](/molmil-images/mine/8sl0) | |
8SKN
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![BU of 8skn by Molmil](/molmil-images/mine/8skn) | |
8SKM
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![BU of 8skm by Molmil](/molmil-images/mine/8skm) | |
8SKJ
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![BU of 8skj by Molmil](/molmil-images/mine/8skj) | Crystal structure of a Nanobody bound to the V5 peptide. | 分子名称: | NbA1, V5 Epitope Tag Peptide | 著者 | Zaghal, M, Matte, K, Venes, A, Patel, S, Laroche, G, Sarvan, S, Joshi, M, Couture, J.F, Giguere, P.M. | 登録日 | 2023-04-19 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signaling. J.Biol.Chem., 299, 2023
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8SKH
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![BU of 8skh by Molmil](/molmil-images/mine/8skh) | Co-structure of SARS-CoV-2 (COVID-19 with covalent pyrazoline based inhibitors | 分子名称: | 2-chloro-1-[(4R,5R)-3,4,5-triphenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one, 3C-like proteinase nsp5 | 著者 | Knapp, M.S, Ornelas, E. | 登録日 | 2023-04-19 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | X-RAY DIFFRACTION (1.882 Å) | 主引用文献 | Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors. Chembiochem, 24, 2023
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8SKF
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8SK5
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![BU of 8sk5 by Molmil](/molmil-images/mine/8sk5) | Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH | 著者 | Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y. | 登録日 | 2023-04-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants. Sci Rep, 13, 2023
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8SK4
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![BU of 8sk4 by Molmil](/molmil-images/mine/8sk4) | |
8SK0
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![BU of 8sk0 by Molmil](/molmil-images/mine/8sk0) | Crystal structure of EvdS6 decarboxylase in ligand bound state | 分子名称: | CITRATE ANION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Sharma, P, Frigo, L, Dulin, C.C, Bachmann, B.O, Iverson, T.M. | 登録日 | 2023-04-18 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | EvdS6 is a bifunctional decarboxylase from the everninomicin gene cluster. J.Biol.Chem., 299, 2023
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8SJK
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![BU of 8sjk by Molmil](/molmil-images/mine/8sjk) | Pembrolizumab Caffeine crystal | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY HEAVY CHAIN, ANTIBODY LIGHT CHAIN, ... | 著者 | Larpent, P, Codan, L, Bothe, J.R, Stueber, D, Reichert, P, Fischmann, T, Su, Y, Pabit, S, Gupta, S, Iuzzolino, L, Cote, A. | 登録日 | 2023-04-18 | 公開日 | 2024-04-24 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Small-Angle X-ray Scattering as a Powerful Tool for Phase and Crystallinity Assessment of Monoclonal Antibody Crystallites in Support of Batch Crystallization. Mol Pharm., 2024
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8SJJ
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![BU of 8sjj by Molmil](/molmil-images/mine/8sjj) | X-ray structure of the metastable SEPT14-SEPT7 heterodimeric coiled coil | 分子名称: | DI(HYDROXYETHYL)ETHER, SODIUM ION, Septin 7, ... | 著者 | Cavini, I.A, Pereira, H.M, Garratt, R.C. | 登録日 | 2023-04-18 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.781 Å) | 主引用文献 | X-ray structure of the metastable SEPT14-SEPT7 coiled coil reveals a hendecad region crucial for heterodimerization. Acta Crystallogr D Struct Biol, 79, 2023
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8SJ9
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![BU of 8sj9 by Molmil](/molmil-images/mine/8sj9) | Crystal structure of the H1 hemagglutinin COBRA X6 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Dzimianski, J.V, DuBois, R.M. | 登録日 | 2023-04-17 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6. Structure, 2024
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8SIX
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![BU of 8six by Molmil](/molmil-images/mine/8six) | Structure of Compound 13 bound to the CHK1 10-point mutant | 分子名称: | (1S)-N-(7-chloro-6-{4-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperazin-1-yl}isoquinolin-3-yl)-6-oxaspiro[2.5]octane-1-carboxamide, Serine/threonine-protein kinase Chk1 | 著者 | Palte, R.L. | 登録日 | 2023-04-17 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023
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8SIW
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![BU of 8siw by Molmil](/molmil-images/mine/8siw) | Structure of Compound 5 bound to the CHK1 10-point mutant | 分子名称: | (1S,2S)-N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)cyclopropane-1-carboxamide, Serine/threonine-protein kinase Chk1 | 著者 | Palte, R.L. | 登録日 | 2023-04-17 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.877 Å) | 主引用文献 | Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023
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8SIV
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![BU of 8siv by Molmil](/molmil-images/mine/8siv) | Structure of Compound 2 bound to the CHK1 10-point mutant | 分子名称: | N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)cyclopropanecarboxamide, Serine/threonine-protein kinase Chk1 | 著者 | Palte, R.L. | 登録日 | 2023-04-17 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.759 Å) | 主引用文献 | Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023
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8SIJ
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8SIH
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![BU of 8sih by Molmil](/molmil-images/mine/8sih) | Crystal Structure of PRMT4 with Compound YD1-289 | 分子名称: | 5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine, CALCIUM ION, Histone-arginine methyltransferase CARM1 | 著者 | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-16 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal Structure of PRMT4 with Compound YD1-289 To be published
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8SIE
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![BU of 8sie by Molmil](/molmil-images/mine/8sie) | Pendrin in complex with bicarbonate | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, BICARBONATE ION, CHOLESTEROL, ... | 著者 | Wang, L, Hoang, A, Zhou, M. | 登録日 | 2023-04-16 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat Commun, 15, 2024
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