PDB: 31188 件ウェブページステータス検索Chemie searchBIRD

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6OJW	Crystal structure of Sphingomonas paucimobilis TMY1009 holo-LsdA 分子名称: FE (III) ION, GLYCEROL, Lignostilbene-alpha,beta-dioxygenase isozyme I, ... 著者 Kuatsjah, E, Verstraete, M.M, Kobylarz, M.J, Liu, A.K.N, Murphy, M.E.P, Eltis, L.D. 登録日 2019-04-12 公開日 2019-07-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J.Biol.Chem., 294, 2019
6OH7	Crystal structure of (E)-biformene synthase LrdC from Streptomyces sp. strain K155 in complex with Mg 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Labdane-related diterpene synthase, ... 著者 Centeno-Leija, S, Serrano-Posada, H. 登録日 2019-04-04 公開日 2019-04-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 The structure of (E)-biformene synthase provides insights into the biosynthesis of bacterial bicyclic labdane-related diterpenoids. J.Struct.Biol., 207, 2019
6O9S	Crystal structure of Staphylococcus aureus MecR1 antibiotic-sensor domain in complex with avibactam 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Methicillin resistance mecR1 protein, SULFATE ION 著者 Alexander, J.A.N, Strynadka, N.C.J. 登録日 2019-03-14 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus . J.Biol.Chem., 295, 2020
6O9W	Crystal structure of Staphylococcus aureus BlaR1 antibiotic-sensor domain in complex with avibactam 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Regulatory protein BlaR1 著者 Alexander, J.A.N, Strynadka, N.C.J. 登録日 2019-03-15 公開日 2020-06-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus . J.Biol.Chem., 295, 2020
6OOW	The crystal structure of 4-ethylbenzoate bound to T252A mutant of CYP199A4 分子名称: 4-ethylbenzoic acid, CHLORIDE ION, Cytochrome P450, ... 著者 Coleman, T, Bruning, J.B, Bell, S.G. 登録日 2019-04-23 公開日 2020-04-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural investigation of the interplay between the substrate and the acid-alcohol pair of residues in cytochrome P450 enzymes To Be Published
6OQI	CDK2 in complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine) 分子名称: 5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4S)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine, Cyclin-dependent kinase 2 著者 Murray, J.M. 登録日 2019-04-26 公開日 2020-07-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg.Med.Chem.Lett., 29, 2019
6OHE	Alpha-L-fucosidase AlfC D200A in complex with Fuca(1,6)GlcNAc 分子名称: AlfC, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Klontz, E.H, Sundberg, E.J. 登録日 2019-04-05 公開日 2020-04-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation. Nat Commun, 11, 2020
6OS5	Crystal structure of CymD prenyltransferase complexed with L-tryptophan 分子名称: BENZOIC ACID, CymD prenyltransferase, DIPHOSPHATE, ... 著者 Roose, B.W, Christianson, D.W. 登録日 2019-05-01 公開日 2019-07-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD. Biochemistry, 58, 2019
6OFY	Crystal Structure of Arachidonic Acid bound to V349I murine COX-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ARACHIDONIC ACID, ... 著者 Malkowski, M.G. 登録日 2019-04-01 公開日 2020-02-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex. Biochemistry, 58, 2019
6O5J	Crystal Structure of DAD2 bound to quinazolinone derivative 分子名称: 1-(4-hydroxy-3-nitrophenyl)quinazoline-2,4(1H,3H)-dione, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Hamiaux, C. 登録日 2019-03-03 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode. Biochem.J., 476, 2019
6OKF	Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto Acyl Carrier Protein, AcpP 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... 著者 Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. 登録日 2019-04-12 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020
5TUH	Archaellum periplasmic stator protein FlaG from Sulfolobus acidocaldarius 分子名称: Flagellar biosynthesis protein FlaG, GLYCEROL 著者 Tsai, C.-L, Tainer, J.A. 登録日 2016-11-06 公開日 2018-01-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility. Nat Microbiol, 5, 2020
6BA1	Purine-Preferring Ribonucleoside Hydrolase from Gardnerella vaginalis 分子名称: CALCIUM ION, Inosine-uridine preferring nucleoside hydrolase 著者 Renner, N, Jacques, D.A. 登録日 2017-10-11 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Inosine-Uridine Preferring Ribonucleoside Hydrolase from Gardnerella vaginalis To Be Published
6P4B	HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) 分子名称: CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain, ... 著者 Langley, D.B, Christ, D. 登録日 2019-05-27 公開日 2020-05-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
6P4C	HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F 分子名称: CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain 著者 Langley, D.B, Christ, D. 登録日 2019-05-27 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
6P4D	Hen egg lysozyme (HEL) containing three point mutations (HEL3x): R21Q, R73E, and D101R 分子名称: CHLORIDE ION, GLYCEROL, Lysozyme C, ... 著者 Langley, D.B, Christ, D. 登録日 2019-05-27 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
6P05	Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with compound 27 分子名称: Bromodomain-containing protein 4, GLYCEROL, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide 著者 Ratia, K.M, Xiong, R, Li, Y, Zhao, J, Gutgesell, L.M, Shen, Z, Dye, K, Dubrovyskyii, O, Zhao, H, Huang, F, Tonetti, D.A, Thatcher, G.R. 登録日 2019-05-16 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J.Med.Chem., 63, 2020
6BTY	Crystal structure of the PI3KC2alpha C2 domain in space group P41212 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 著者 Chen, K.-E, Collins, B.M. 登録日 2017-12-08 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.678 Å) 主引用文献 Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26, 2018
6C17	Crystal Structure of Ketosteroid Isomerase D40N mutant from Pseudomonas Putida (pKSI) bound to 3,4-dinitrophenol 分子名称: 3,4-dinitrophenol, MAGNESIUM ION, Steroid Delta-isomerase 著者 Yabukarski, F, Pinney, M, Herschlag, D. 登録日 2018-01-04 公開日 2018-07-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural Coupling Throughout the Active Site Hydrogen Bond Networks of Ketosteroid Isomerase and Photoactive Yellow Protein. J. Am. Chem. Soc., 140, 2018
6BX4	The crystal structure of fluoride channel Fluc Ec2 with Monobody S9 分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, FLUORIDE ION, Fluoride ion transporter CrcB, ... 著者 Turman, D.L, Miller, C. 登録日 2017-12-16 公開日 2018-02-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Molecular Interactions between a Fluoride Ion Channel and Synthetic Protein Blockers. Biochemistry, 57, 2018
6BY9	Crystal structure of EHMT1 分子名称: Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION 著者 Dong, A, Wei, Y, Li, A, Tempel, W, Han, S, Sunnerhagen, M, Penn, L, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) 登録日 2017-12-20 公開日 2018-01-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of EHMT1 to be published
6BXQ	Crystal Structure of HLA-B*57:01 with an HIV peptide RKV 分子名称: Beta-2-microglobulin, HIV peptide RKV, MHC class I antigen 著者 Gras, S, Rossjohn, J. 登録日 2017-12-18 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics. Proteomics, 18, 2018
6C3J	The crystal structure of 4-(thiophen-3-yl)benzoate-bound CYP199A4 分子名称: 4-(thiophen-3-yl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... 著者 Coleman, T, Bruning, J.B, Bell, S.G. 登録日 2018-01-09 公開日 2019-01-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 The crystal structure of 4-(thiophen-3-yl)benzoate-bound CYP199A4 To Be Published
6OKC	Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C12-crypto Acyl Carrier Protein, AcpP 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide 著者 Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. 登録日 2019-04-12 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020
6OKG	Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16-crypto Acyl Carrier Protein, AcpP 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N-[2-(hexadecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... 著者 Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. 登録日 2019-04-12 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020

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