PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

---

8EM5	Mycobacterium thermoresistible MmpS5 分子名称: DODECAETHYLENE GLYCOL, GLYCEROL, IODIDE ION, ... 著者 Cuthbert, B.J, Goulding, C.W. 登録日 2022-09-26 公開日 2023-09-27 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics, 16, 2024
8P6G	Crystal structure of the improved version of the Genetically Encoded Green Calcium Indicator YTnC2-5 分子名称: DI(HYDROXYETHYL)ETHER, Genetically Encoded Green Calcium Indicator YTnC2-5 based on Troponin C from toadfish 著者 Boyko, K.M, Nikolaeva, A.Y, Subach, O.M, Vlaskina, A.V, Agapova, Y.K, Popov, V.O, Subach, F.V. 登録日 2023-05-26 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 YTnC2, an improved genetically encoded green calcium indicator based on toadfish troponin C. Febs Open Bio, 13, 2023
8P37	Structure a catalytically inactive mutant of the IMP dehydrogenase related protein GUAB3 from Synechocystis PCC 6803 分子名称: IMP dehydrogenase subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, XANTHOSINE-5'-MONOPHOSPHATE 著者 Hernandez-Gomez, A, Fernandez-Justel, D, Buey, R.M. 登録日 2023-05-17 公開日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.219 Å) 主引用文献 GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution. Structure, 31, 2023
7UVA	Crystal structure of KDM2A histone demethylase catalytic domain in complex with an H3C36 peptide modified by UNC8015 分子名称: FE (III) ION, Histone H3.2, Lysine-specific demethylase 2A, ... 著者 Budziszewski, G.R, Azzam, D.N, Spangler, C.J, Skrajna, A, Foley, C.A, James, L.I, Frye, S.V, McGinty, R.K. 登録日 2022-04-29 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural basis of paralog-specific KDM2A/B nucleosome recognition. Nat.Chem.Biol., 19, 2023
7UI4	Crystal structure of the DNA preQ0 insertase DpdA 分子名称: DNA-guanine transglycosylase, ZINC ION 著者 Hung, S.-H, Swairjo, M.A. 登録日 2022-03-28 公開日 2023-02-22 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 7-Deazaguanines in DNA: functional and structural elucidation of a DNA modification system. Nucleic Acids Res., 51, 2023
6X7E	Co-bound structure of an engineered protein trimer, TriCyt3, with delta isomerism at the hexahistidine coordination site 分子名称: CHLORIDE ION, COBALT (II) ION, HEME C, ... 著者 Tezcan, F.A, Kakkis, A. 登録日 2020-05-29 公開日 2020-09-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9987 Å) 主引用文献 Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites. Angew.Chem.Int.Ed.Engl., 59, 2020
8OJX	Streptavidin S112YK121E artificial metalloenzyme for carboamination 分子名称: IRIDIUM ION, Streptavidin, trichloro{(1,2,3,4,5-eta)-1,2,3,4-tetramethyl-5-[2-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)ethyl]cyclopentadienyl}rhodium(1+) 著者 Igareta, N.V, Ward, T.R. 登録日 2023-03-25 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Streptavidin WT artificial metalloenzyme for carboamination To Be Published
6X83	Crystal Structure of TNFalpha with fragment compound 6 分子名称: 1-benzyl-1H-benzimidazole, Tumor necrosis factor 著者 Longenecker, K.L, Stoll, V.S. 登録日 2020-06-01 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Development of Orally Efficacious Allosteric Inhibitors of TNF alpha via Fragment-Based Drug Design. J.Med.Chem., 64, 2021
8EM3	Carbonic Anhydrase II in complex with the diaryl urea molecule J2 分子名称: 4-[(3-methoxyphenyl)carbamamido]benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Combs, J, McKenna, R. 登録日 2022-09-26 公開日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Prospective Diaryl urea: Prevent growth of breast cancer cells by inhibition and down-regulation of Carbonic Anhydrase IX. To Be Published
5LFR	Crystal structure of glycosylated Myelin-associated glycoprotein (MAG) Ig1-3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Myelin-associated glycoprotein, ... 著者 Pronker, M.F, Janssen, B.J.C. 登録日 2016-07-04 公開日 2016-12-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structural basis of myelin-associated glycoprotein adhesion and signalling. Nat Commun, 7, 2016
7UVH	Pfs230 domain 1 bound by RUPA-32 Fab 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AMMONIUM ION, ... 著者 Ivanochko, D, Newton, J, Julien, J.P. 登録日 2022-05-02 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230. Immunity, 56, 2023
8F22	HIV-CA Disulfide linked Hexamer bound to 11l capsid inhibitor. 分子名称: Capsid protein p24, Nalpha-{[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]acetyl}-N-(4-methoxyphenyl)-N-methyl-L-phenylalaninamide 著者 Barnett, M.J, Goldstone, D.C. 登録日 2022-11-06 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of a benzosulfonamide based inhibitor - bound to a disulfide stabilised HIV-1 capsid hexamer Biorxiv, 2023
8EGZ	Engineered tyrosine synthase (TmTyrS1) derived from T. maritima TrpB with Ser bound as the amino-acrylate intermediate 分子名称: 1,2-ETHANEDIOL, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, POTASSIUM ION, ... 著者 Porter, N.J, Almhjell, P.J, Arnold, F.H. 登録日 2022-09-13 公開日 2023-10-04 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The beta-subunit of tryptophan synthase is a latent tyrosine synthase. Nat.Chem.Biol., 20, 2024
7UK7	YjfC from Escherichia coli K-12 in complex with ADP, Mg2+ and SO4 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative acid--amine ligase YjfC, ... 著者 Pederick, J.L, Bruning, J.B. 登録日 2022-03-31 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Escherichia coli YgiC and YjfC Possess Peptide─Spermidine Ligase Activity. Biochemistry, 62, 2023
8EO7	Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution 分子名称: beta-lactamase 著者 Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S. 登録日 2022-10-02 公開日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published
6X9B	Structure of proline utilization A with cis-4-hydroxy-D-proline bound in the L-glutamate-gamma-semialdehyde dehydrogenase active site 分子名称: (4R)-4-hydroxy-D-proline, Bifunctional protein PutA, DI(HYDROXYETHYL)ETHER, ... 著者 Tanner, J.J, Campbell, A.C. 登録日 2020-06-02 公開日 2020-12-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-gamma-semialdehyde dehydrogenase active site of bifunctional proline utilization A. Arch.Biochem.Biophys., 698, 2020
5LGV	GlgE isoform 1 from Streptomyces coelicolor E423A mutant soaked in maltooctaose 分子名称: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Syson, K, Stevenson, C.E.M, Mia, F, Barclay, J.E, Tang, M, Gorelik, A, Rashid, A.M, Lawson, D.M, Bornemann, S. 登録日 2016-07-08 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Ligand-bound structures and site-directed mutagenesis identify the acceptor and secondary binding sites of Streptomyces coelicolor maltosyltransferase GlgE. J.Biol.Chem., 291, 2016
8EH0	Engineered tyrosine synthase (TmTyrS1) derived from T. maritima TrpB with Ser bound as the amino-acrylate intermediate and complexed with quinoline N-oxide 分子名称: 1,2-ETHANEDIOL, 1-oxo-1lambda~5~-quinoline, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, ... 著者 Porter, N.J, Almhjell, P.J, Arnold, F.H. 登録日 2022-09-13 公開日 2023-10-04 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The beta-subunit of tryptophan synthase is a latent tyrosine synthase. Nat.Chem.Biol., 20, 2024
6XB0	Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design 分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE 著者 Kneller, D.W, Kovalevsky, A, Coates, L. 登録日 2020-06-05 公開日 2020-06-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design. Iucrj, 7, 2020
8EML	Crystal Structure of Gsx2 Homeodomain in Complex with DNA 分子名称: DNA (5'-D(P*GP*AP*GP*CP*TP*AP*AP*TP*TP*AP*AP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*TP*TP*AP*AP*TP*TP*AP*GP*CP*TP*C)-3'), GS homeobox 2, ... 著者 Webb, J.A, Kovall, R.A. 登録日 2022-09-28 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal Structure of Gsx2 Homeodomain in Complex with DNA To Be Published
5LKQ	Protease domain of RadA 分子名称: DNA repair protein RadA 著者 Rapisarda, C, Fronzes, R. 登録日 2016-07-22 公開日 2017-06-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.498 Å) 主引用文献 Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension. Nat Commun, 8, 2017
6XB6	Structure of Danaus plexippus poxin cGAMP nuclease 分子名称: Poxin 著者 Eaglesham, J.B, McCarty, K.L, Kranzusch, P.J. 登録日 2020-06-05 公開日 2020-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict. Elife, 9, 2020
8OIO	Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Kelch-like protein 12, ... 著者 Dalietou, E.V, Chen, Z, Ramdass, A.E, Manning, C, Richardson, W, Aitmakhanova, K, Platt, M, Pike, A.C.W, Fedorov, O, Brennan, P, Bullock, A.N. 登録日 2023-03-23 公開日 2024-04-03 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.954 Å) 主引用文献 Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide To Be Published
8OK1	WD repeat containing protein 5 (WDR5)- N225A mutant 分子名称: Glutathione S-transferase class-mu 26 kDa isozyme,WD repeat-containing protein 5 著者 Wolf, E, Boergel, A. 登録日 2023-03-26 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 A structural competition involving WDR5 times circadian oscillations To Be Published
8EKG	MHETase variant Thr159Val, Met192Tyr, Tyr252Phe, Tyr503Trp 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Saunders, J.W, Frkic, R.L, Jackson, C.J. 登録日 2022-09-20 公開日 2023-10-18 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design. Biochemistry, 63, 2024

<668669670671672673674675676677678679680681682683>