7UVA

Crystal structure of KDM2A histone demethylase catalytic domain in complex with an H3C36 peptide modified by UNC8015

Summary for 7UVA

Entry DOI	10.2210/pdb7uva/pdb
Descriptor	Lysine-specific demethylase 2A, Histone H3.2, FE (III) ION, ... (6 entities in total)
Functional Keywords	demethylase, histone, inhibitor, gene regulation
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	6
Total formula weight	96922.31
Authors	Budziszewski, G.R.,Azzam, D.N.,Spangler, C.J.,Skrajna, A.,Foley, C.A.,James, L.I.,Frye, S.V.,McGinty, R.K. (deposition date: 2022-04-29, release date: 2023-02-22, Last modification date: 2023-10-25)
Primary citation	Spangler, C.J.,Skrajna, A.,Foley, C.A.,Nguyen, A.,Budziszewski, G.R.,Azzam, D.N.,Arteaga, E.C.,Simmons, H.C.,Smith, C.B.,Wesley, N.A.,Wilkerson, E.M.,McPherson, J.E.,Kireev, D.,James, L.I.,Frye, S.V.,Goldfarb, D.,McGinty, R.K. Structural basis of paralog-specific KDM2A/B nucleosome recognition. Nat.Chem.Biol., 19:624-632, 2023 Cited by PubMed: 36797403 DOI: 10.1038/s41589-023-01256-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation