7UVA
Crystal structure of KDM2A histone demethylase catalytic domain in complex with an H3C36 peptide modified by UNC8015
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Lysine-specific demethylase 2A | polymer | 330 | 39162.5 | 2 | UniProt (P59997) Pfam (PF17811) In PDB | Mus musculus (house mouse) | F-box and leucine-rich repeat protein 11,F-box/LRR-repeat protein 11,JmjC domain-containing histone demethylation protein 1A,[Histone-H3]-lysine-36 demethylase 1A |
2 | B, E | Lysine-specific demethylase 2A | polymer | 69 | 7666.0 | 2 | UniProt (P59997) In PDB | Mus musculus (house mouse) | F-box and leucine-rich repeat protein 11,F-box/LRR-repeat protein 11,JmjC domain-containing histone demethylation protein 1A,[Histone-H3]-lysine-36 demethylase 1A |
3 | C, F | Histone H3.2 | polymer | 13 | 1359.6 | 2 | UniProt (Q71DI3) In PDB | Homo sapiens | H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o |
4 | A, D | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
5 | A, D | N-heptanoyl-N-hydroxy-beta-alanine | non-polymer | 217.3 | 2 | Chemie (OH0) | |||
6 | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A, D: 36 - 364 (UniProt: P59997)
B, E: 450 - 517 (UniProt: P59997)
C, F: 29 - 41 (UniProt: Q71DI3)
PDB | External Database | Details |
---|---|---|
Met 35 | - | initiating methionine |
Arg 159 | Trp 159 | conflict |
Met 202 | Ile 202 | conflict |
PDB | External Database | Details |
---|---|---|
Met 449 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Cys 36 | Lys 37 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 96376.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 546.2 | |
All* | Total formula weight | 96922.3 |