7UVA

Crystal structure of KDM2A histone demethylase catalytic domain in complex with an H3C36 peptide modified by UNC8015

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Lysine-specific demethylase 2A	polymer	330	39162.5	2	UniProt (P59997) Pfam (PF17811) In PDB	Mus musculus (house mouse)	F-box and leucine-rich repeat protein 11,F-box/LRR-repeat protein 11,JmjC domain-containing histone demethylation protein 1A,[Histone-H3]-lysine-36 demethylase 1A
2	B, E	Lysine-specific demethylase 2A	polymer	69	7666.0	2	UniProt (P59997) In PDB	Mus musculus (house mouse)	F-box and leucine-rich repeat protein 11,F-box/LRR-repeat protein 11,JmjC domain-containing histone demethylation protein 1A,[Histone-H3]-lysine-36 demethylase 1A
3	C, F	Histone H3.2	polymer	13	1359.6	2	UniProt (Q71DI3) In PDB	Homo sapiens	H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o
4	A, D	FE (III) ION	non-polymer		55.8	2	Chemie (FE)
5	A, D	N-heptanoyl-N-hydroxy-beta-alanine	non-polymer		217.3	2	Chemie (OH0)
6		water	water		18.0	429	Chemie (HOH)

Sequence modifications

A, D: 36 - 364 (UniProt: P59997)

PDB	External Database	Details
Met 35	-	initiating methionine
Arg 159	Trp 159	conflict
Met 202	Ile 202	conflict

B, E: 450 - 517 (UniProt: P59997)

PDB	External Database	Details
Met 449	-	initiating methionine

C, F: 29 - 41 (UniProt: Q71DI3)

PDB	External Database	Details
Cys 36	Lys 37	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	96376.1
Non-Polymers*	Number of molecules	4
	Total formula weight	546.2
All*	Total formula weight	96922.3

*Water molecules are not included.