8F22

HIV-CA Disulfide linked Hexamer bound to 11l capsid inhibitor.

Summary for 8F22

• Entry DOI: 10.2210/pdb8f22/pdb
• Descriptor: Capsid protein p24, Nalpha-{[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]acetyl}-N-(4-methoxyphenyl)-N-methyl-L-phenylalaninamide (3 entities in total)
• Functional Keywords: hiv-1, human immunodeficiency virus, capsid, hiv-ca, 11l, capsid inhibitor, hiv restriction, viral protein
• Biological source: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
• Total number of polymer chains: 12
• Total formula weight: 299833.99

Authors

Barnett, M.J.,Goldstone, D.C. (deposition date: 2022-11-06, release date: 2023-09-13)

• Primary citation: Barnett, M.,Sun, L.,Xu, S.,Liu, X.,Zhan, P.,Goldstone, D.C.; Structure of a benzosulfonamide based inhibitor - bound to a disulfide stabilised HIV-1 capsid hexamer; Biorxiv, 2023; DOI: 10.1101/2023.08.16.553511

Experimental method

X-RAY DIFFRACTION (2.5 Å)