8F22
HIV-CA Disulfide linked Hexamer bound to 11l capsid inhibitor.
Summary for 8F22
| Entry DOI | 10.2210/pdb8f22/pdb |
| Descriptor | Capsid protein p24, Nalpha-{[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]acetyl}-N-(4-methoxyphenyl)-N-methyl-L-phenylalaninamide (3 entities in total) |
| Functional Keywords | hiv-1, human immunodeficiency virus, capsid, hiv-ca, 11l, capsid inhibitor, hiv restriction, viral protein |
| Biological source | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) |
| Total number of polymer chains | 12 |
| Total formula weight | 299833.99 |
| Authors | Barnett, M.J.,Goldstone, D.C. (deposition date: 2022-11-06, release date: 2023-09-13, Last modification date: 2024-10-16) |
| Primary citation | Barnett, M.,Sun, L.,Xu, S.,Liu, X.,Zhan, P.,Goldstone, D.C. Structure of a benzosulfonamide based inhibitor - bound to a disulfide stabilised HIV-1 capsid hexamer Biorxiv, 2023 Cited by DOI: 10.1101/2023.08.16.553511PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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