8F22
HIV-CA Disulfide linked Hexamer bound to 11l capsid inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Capsid protein p24 | polymer | 224 | 24696.3 | 12 | UniProt (P12497) Pfam (PF19317) | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | CA |
| 2 | M, N, O, P, Q... (A, B, C, D, E...) | Nalpha-{[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]acetyl}-N-(4-methoxyphenyl)-N-methyl-L-phenylalaninamide | non-polymer | 579.7 | 6 | Chemie (XBQ) | |||
| 3 | S, T, U, V, W... (A, B, C, D, E...) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 224 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Cys 14 | Ala 146 | engineered mutation |
| Cys 45 | Glu 177 | engineered mutation |
| Ala 184 | Trp 316 | engineered mutation |
| Ala 185 | Met 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 296356.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3478.0 | |
| All* | Total formula weight | 299834.0 |
