1VYD
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![BU of 1vyd by Molmil](/molmil-images/mine/1vyd) | Crystal structure of cytochrome C2 mutant G95E | 分子名称: | CYTOCHROME C2, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Dumortier, C, Fitch, J, Van Petegem, F, Vermeulen, W, Meyer, T.E, Van Beeumen, J.J, Cusanovich, M.A. | 登録日 | 2004-04-27 | 公開日 | 2004-06-17 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Protein Dynamics in the Region of the Sixth Ligand Methionine Revealed by Studies of Imidazole Binding to Rhodobacter Capsulatus Cytochrome C2 Hinge Mutants. Biochemistry, 43, 2004
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5N7Q
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![BU of 5n7q by Molmil](/molmil-images/mine/5n7q) | CRYSTAL STRUCTURE OF MATURE CATHEPSIN D FROM THE TICK IXODES RICINUS (IRCD1) IN COMPLEX WITH THE INHIBITOR PEPSTATIN A | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, PEPSTATIN A, ... | 著者 | Brynda, J, Hanova, I, Hobizalova, R, Mares, M. | 登録日 | 2017-02-21 | 公開日 | 2017-12-27 | 最終更新日 | 2018-06-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite. Cell Chem Biol, 25, 2018
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3J79
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![BU of 3j79 by Molmil](/molmil-images/mine/3j79) | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W. | 登録日 | 2014-06-02 | 公開日 | 2014-07-16 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife, 3, 2014
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5N9Z
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![BU of 5n9z by Molmil](/molmil-images/mine/5n9z) | Rubisco from Thalassiosira hyalina | 分子名称: | 1,2-ETHANEDIOL, 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Andersson, I, Valegard, K. | 登録日 | 2017-02-27 | 公開日 | 2018-03-14 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications. J. Biol. Chem., 293, 2018
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4FMG
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![BU of 4fmg by Molmil](/molmil-images/mine/4fmg) | |
4OIR
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![BU of 4oir by Molmil](/molmil-images/mine/4oir) | Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV | 分子名称: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.105 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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7AXV
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![BU of 7axv by Molmil](/molmil-images/mine/7axv) | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 5-isoquinolinesulfonic acid and PKI (5-24) | 分子名称: | DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ... | 著者 | Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. | 登録日 | 2020-11-10 | 公開日 | 2021-11-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
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7B12
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![BU of 7b12 by Molmil](/molmil-images/mine/7b12) | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid | 分子名称: | ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | 著者 | Musil, D, Klein, M, Crosignani, S. | 登録日 | 2020-11-23 | 公開日 | 2021-12-01 | 最終更新日 | 2023-06-14 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i). J.Med.Chem., 64, 2021
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7AYW
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![BU of 7ayw by Molmil](/molmil-images/mine/7ayw) | |
5NW4
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![BU of 5nw4 by Molmil](/molmil-images/mine/5nw4) | Human cytoplasmic dynein-1 bound to dynactin and an N-terminal construct of BICD2 | 分子名称: | Arp1, Arp11, BICD2N, ... | 著者 | Zhang, K, Foster, H.E, Carter, A.P. | 登録日 | 2017-05-05 | 公開日 | 2017-08-02 | 最終更新日 | 2018-11-21 | 実験手法 | ELECTRON MICROSCOPY (8.7 Å) | 主引用文献 | Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. Cell, 169, 2017
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3JBP
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![BU of 3jbp by Molmil](/molmil-images/mine/3jbp) | Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... | 著者 | Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. | 登録日 | 2015-09-16 | 公開日 | 2015-10-14 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
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4OSQ
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![BU of 4osq by Molmil](/molmil-images/mine/4osq) | Crystal structure of the S505R mutant of TAL effector dHax3 | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*GP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3, ... | 著者 | Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. | 登録日 | 2014-02-13 | 公開日 | 2014-05-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.256 Å) | 主引用文献 | Revisiting the TALE repeat Protein Cell, 5, 2014
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3J5L
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![BU of 3j5l by Molmil](/molmil-images/mine/3j5l) | Structure of the E. coli 50S subunit with ErmBL nascent chain | 分子名称: | 23S ribsomal RNA, 5'-R(*CP*(MA6))-3', 5'-R(*CP*CP*A)-3', ... | 著者 | Arenz, S, Ramu, H, Gupta, P, Berninghausen, O, Beckmann, R, Vazquez-Laslop, N, Mankin, A.S, Wilson, D.N. | 登録日 | 2013-10-23 | 公開日 | 2014-03-26 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide. Nat Commun, 5, 2014
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3JCN
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![BU of 3jcn by Molmil](/molmil-images/mine/3jcn) | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association: Initiation Complex I | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Sprink, T, Ramrath, D.J.F, Yamamoto, H, Yamamoto, K, Loerke, J, Ismer, J, Hildebrand, P.W, Scheerer, P, Buerger, J, Mielke, T, Spahn, C.M.T. | 登録日 | 2016-01-04 | 公開日 | 2016-03-09 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association. Sci Adv, 2, 2016
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4PJB
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![BU of 4pjb by Molmil](/molmil-images/mine/4pjb) | Structure of human MR1-5-OP-RU in complex with human MAIT B-F3-C1 TCR | 分子名称: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Birkinshaw, R.W, Rossjohn, J. | 登録日 | 2014-05-12 | 公開日 | 2014-07-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. J.Exp.Med., 211, 2014
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3NXN
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![BU of 3nxn by Molmil](/molmil-images/mine/3nxn) | X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor | 分子名称: | N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, SULFATE ION, protease covalent dimer | 著者 | Torbeev, V.Y, Kent, S.B.H. | 登録日 | 2010-07-14 | 公開日 | 2011-11-02 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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6ZYX
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![BU of 6zyx by Molmil](/molmil-images/mine/6zyx) | Outer Dynein Arm-Shulin complex - Shulin region from Tetrahymena thermophila | 分子名称: | Dynein heavy chain, outer arm protein, Dynein intermediate chain 2, ... | 著者 | Mali, G.R, Abid Ali, F, Lau, C.K, Carter, A.P. | 登録日 | 2020-08-03 | 公開日 | 2021-01-20 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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6ZXK
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![BU of 6zxk by Molmil](/molmil-images/mine/6zxk) | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement | 分子名称: | Lethal factor, Protective antigen | 著者 | Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S. | 登録日 | 2020-07-29 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state. Plos Pathog., 16, 2020
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5NH2
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![BU of 5nh2 by Molmil](/molmil-images/mine/5nh2) | |
4F75
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![BU of 4f75 by Molmil](/molmil-images/mine/4f75) | |
3NWX
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![BU of 3nwx by Molmil](/molmil-images/mine/3nwx) | X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor | 分子名称: | N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, SULFATE ION, protease | 著者 | Torbeev, V.Y, Kent, S.B.H. | 登録日 | 2010-07-12 | 公開日 | 2011-11-02 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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5O60
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![BU of 5o60 by Molmil](/molmil-images/mine/5o60) | Structure of the 50S large ribosomal subunit from Mycobacterium smegmatis | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Hentschel, J, Burnside, C, Mignot, I, Leibundgut, M, Boehringer, D, Ban, N. | 登録日 | 2017-06-02 | 公開日 | 2017-07-12 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | The Complete Structure of the Mycobacterium smegmatis 70S Ribosome. Cell Rep, 20, 2017
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3NZX
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![BU of 3nzx by Molmil](/molmil-images/mine/3nzx) | Crystal structure of the yeast 20S proteasome in complex with ligand 2c | 分子名称: | Proteasome component C1, Proteasome component C11, Proteasome component C5, ... | 著者 | Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M. | 登録日 | 2010-07-17 | 公開日 | 2011-02-16 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | 20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A. Chemmedchem, 5, 2010
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4FAO
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![BU of 4fao by Molmil](/molmil-images/mine/4fao) | Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ... | 著者 | Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V. | 登録日 | 2012-05-22 | 公開日 | 2012-06-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.357 Å) | 主引用文献 | Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. J.Biol.Chem., 287, 2012
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6ZMX
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![BU of 6zmx by Molmil](/molmil-images/mine/6zmx) | Crystal structure of hemoglobin from turkey (Meleagiris gallopova) crystallized in orthorhombic form at 1.4 Angstrom resolution | 分子名称: | Hemoglobin beta chain, Hemoglobin subunit alpha-A, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Pandian, R, Shobana, N, Sundaresan, S.S, Sayed, Y, Ponnuswamy, M.N. | 登録日 | 2020-07-04 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.389 Å) | 主引用文献 | Structural studies of hemoglobin from two flightless birds, ostrich and turkey: insights into their differing oxygen-binding properties. Acta Crystallogr D Struct Biol, 77, 2021
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