7B12

HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid

Summary for 7B12

• Entry DOI: 10.2210/pdb7b12/pdb
• Descriptor: Proteasome subunit beta type-1, Proteasome subunit beta type-9, Proteasome subunit beta type-3, ... (18 entities in total)
• Functional Keywords: multicatalytic proteinase, 20s proteasome, protease, hydrolase, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 28
• Total formula weight: 694451.39

Authors

Musil, D.,Klein, M.,Crosignani, S. (deposition date: 2020-11-23, release date: 2021-12-01, Last modification date: 2023-06-14)

• Primary citation: Klein, M.,Busch, M.,Friese-Hamim, M.,Crosignani, S.,Fuchss, T.,Musil, D.,Rohdich, F.,Sanderson, M.P.,Seenisamy, J.,Walter-Bausch, G.,Zanelli, U.,Hewitt, P.,Esdar, C.,Schadt, O.; Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i).; J.Med.Chem., 64:10230-10245, 2021; PubMed: 34228444; DOI: 10.1021/acs.jmedchem.1c00604

Experimental method

X-RAY DIFFRACTION (2.43 Å)