7B12
HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 1, M | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 2 | 2, N | Proteasome subunit beta type-4 | polymer | 214 | 23881.2 | 2 | UniProt (P28070) Pfam (PF00227) In PDB | Homo sapiens (Human) | 26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 3 | A, O | Proteasome subunit alpha type-6 | polymer | 242 | 26941.9 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | 27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain |
| 4 | B, P | Proteasome subunit alpha type-2 | polymer | 229 | 25367.9 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 5 | C, Q | Proteasome subunit alpha type-4 | polymer | 248 | 27859.9 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 6 | D, r | Proteasome subunit alpha type-7 | polymer | 235 | 26365.1 | 2 | UniProt (O14818) Pfam (PF00227) Pfam (PF10584) In PDB | Homo sapiens (Human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7 |
| 7 | E, s | Proteasome subunit alpha type-5 | polymer | 232 | 25293.6 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain |
| 8 | F, T | Proteasome subunit alpha type-1 | polymer | 236 | 26503.2 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 9 | G, U | Proteasome subunit alpha type-3 | polymer | 244 | 27200.0 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 10 | H, V | Proteasome subunit beta type-9 | polymer | 199 | 21295.0 | 2 | UniProt (P28065) Pfam (PF00227) In PDB | Homo sapiens (Human) | Low molecular mass protein 2,Macropain chain 7,Multicatalytic endopeptidase complex chain 7,Proteasome chain 7,Proteasome subunit beta-1i,Really interesting new gene 12 protein |
| 11 | J, X | Proteasome subunit beta type-3 | polymer | 204 | 22841.7 | 2 | UniProt (P49720) Pfam (PF00227) In PDB | Homo sapiens (Human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 12 | K, Y | Proteasome subunit beta type-2 | polymer | 197 | 22462.8 | 2 | UniProt (P49721) Pfam (PF00227) In PDB | Homo sapiens (Human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 13 | L, Z | Proteasome subunit beta type-8 | polymer | 203 | 22557.5 | 2 | UniProt (P28062) Pfam (PF00227) In PDB | Homo sapiens (Human) | Low molecular mass protein 7,Macropain subunit C13,Multicatalytic endopeptidase complex subunit C13,Proteasome component C13,Proteasome subunit beta-5i,Really interesting new gene 10 protein |
| 14 | i, w | Proteasome subunit beta type-10 | polymer | 223 | 23428.9 | 2 | UniProt (P40306) Pfam (PF00227) Pfam (PF12465) In PDB | Homo sapiens (Human) | Low molecular mass protein 10,Macropain subunit MECl-1,Multicatalytic endopeptidase complex subunit MECl-1,Proteasome MECl-1,Proteasome subunit beta-2i |
| 15 | 1, K, L, Y | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 16 | A, L, O, Z, i... | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 17 | H, L, V, Z, i... | ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid | non-polymer | 446.3 | 6 | Chemie (SKN) | |||
| 18 | water | water | 18.0 | 996 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 691155.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3296.1 | |
| All* | Total formula weight | 694451.4 |
