5N7Q

CRYSTAL STRUCTURE OF MATURE CATHEPSIN D FROM THE TICK IXODES RICINUS (IRCD1) IN COMPLEX WITH THE INHIBITOR PEPSTATIN A

Summary for 5N7Q

Entry DOI	10.2210/pdb5n7q/pdb
Related	5N70 5N71 5N7N
Related PRD ID	PRD_000557
Descriptor	Putative cathepsin d, PEPSTATIN A, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	Ixodes ricinus (Common tick) More
Total number of polymer chains	4
Total formula weight	75144.46
Authors	Brynda, J.,Hanova, I.,Hobizalova, R.,Mares, M. (deposition date: 2017-02-21, release date: 2017-12-27, Last modification date: 2018-06-13)
Primary citation	Hanova, I.,Brynda, J.,Houstecka, R.,Alam, N.,Sojka, D.,Kopacek, P.,Maresova, L.,Vondrasek, J.,Horn, M.,Schueler-Furman, O.,Mares, M. Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite. Cell Chem Biol, 25:318-329.e4, 2018 Cited by PubMed: 29396291 DOI: 10.1016/j.chembiol.2018.01.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation