5N7Q
CRYSTAL STRUCTURE OF MATURE CATHEPSIN D FROM THE TICK IXODES RICINUS (IRCD1) IN COMPLEX WITH THE INHIBITOR PEPSTATIN A
Summary for 5N7Q
Entry DOI | 10.2210/pdb5n7q/pdb |
Related | 5N70 5N71 5N7N |
Related PRD ID | PRD_000557 |
Descriptor | Putative cathepsin d, PEPSTATIN A, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | Ixodes ricinus (Common tick) More |
Total number of polymer chains | 4 |
Total formula weight | 75144.46 |
Authors | Brynda, J.,Hanova, I.,Hobizalova, R.,Mares, M. (deposition date: 2017-02-21, release date: 2017-12-27, Last modification date: 2018-06-13) |
Primary citation | Hanova, I.,Brynda, J.,Houstecka, R.,Alam, N.,Sojka, D.,Kopacek, P.,Maresova, L.,Vondrasek, J.,Horn, M.,Schueler-Furman, O.,Mares, M. Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite. Cell Chem Biol, 25:318-329.e4, 2018 Cited by PubMed: 29396291DOI: 10.1016/j.chembiol.2018.01.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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