PDB: 31489 件ウェブページステータス検索Chemie searchBIRD

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6MHF	Galphai3 co-crystallized with GIV/Girdin 分子名称: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Girdin, ... 著者 Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. 登録日 2018-09-17 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
5V5X	Protocadherin gammaB7 EC3-6 cis-dimer structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Goodman, K.M, Mannepalli, S, Bahna, F, Honig, B, Shapiro, L. 登録日 2017-03-15 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Protocadherin cis-dimer architecture and recognition unit diversity. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6G4G	Full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) including the SMB domains but with a partially disordered active site structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Dohler, C, Zebisch, M, Strater, N. 登録日 2018-03-27 公開日 2018-11-07 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain. Acta Crystallogr F Struct Biol Commun, 74, 2018
6VBZ	Crystal structure of the rat MLKL pseudokinase domain 分子名称: MANGANESE (II) ION, Mixed lineage kinase domain-like pseudokinase 著者 Davies, K.A, Czabotar, P.E. 登録日 2019-12-19 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.192 Å) 主引用文献 Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11, 2020
6PJ7	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane 分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG 著者 Urban, S, Cho, S. 登録日 2019-06-28 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6Y5O	The crystal structure of glycogen phosphorylase in complex with 20 分子名称: 2-(4-fluorophenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form 著者 Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. 登録日 2020-02-25 公開日 2020-08-19 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
8KFQ	The crystal structure of EGFR(T797M/L858R) with small molecule inhibitor B6 分子名称: Epidermal growth factor receptor, SULFATE ION, ~{N}-[3-[[6-chloranyl-2-[(1-ethylpyrazol-4-yl)amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide 著者 Wu, C, Ouyang, L. 登録日 2023-08-16 公開日 2024-08-21 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structure of EGFR(T979M/L858R) with small molecule inhibitor B6 To Be Published
6MJE	Structure of Candida glabrata Csm1: S. cerevisiae Dsn1 complex 分子名称: Dsn1p, Monopolin complex subunit CSM1 著者 Singh, N, Corbett, K.D. 登録日 2018-09-20 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The molecular basis of monopolin recruitment to the kinetochore. Chromosoma, 128, 2019
5DJ7	S. erythraea trypsin acyl-enzyme 分子名称: Trypsin 著者 Blankenship, E, Lodowski, D.T. 登録日 2015-09-01 公開日 2017-03-08 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (0.87 Å) 主引用文献 High resolution structures of S. erythraeus trypsin throughout the catalytic cycle To be Published
6YA6	Minimal construct of Cdc7-Dbf4 bound to XL413 分子名称: 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one, BORIC ACID, CHLORIDE ION, ... 著者 Dick, S.D, Cherepanov, P. 登録日 2020-03-11 公開日 2020-05-27 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Structure, 28, 2020
6PBJ	The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with Gly190Pro mutation 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... 著者 Jiao, W, Fan, Y, Blackmore, N.J, Parker, E.J. 登録日 2019-06-13 公開日 2020-04-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis . J.Biol.Chem., 295, 2020
6G66	Crystal structure of a parallel seven-helix coiled coil CC-Type2-IV 分子名称: CC-Type2-IV, GLYCEROL 著者 Rhys, G.G, Brady, R.L, Woolfson, D.N. 登録日 2018-04-01 公開日 2018-10-17 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nat Commun, 9, 2018
7CC2	Strategic design of catalytic lysine-targeting reversible covalent BCR-ABL Inhibitors 分子名称: Tyrosine-protein kinase ABL1, [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]boronic acid 著者 Anantharajan, J, Baburajendran, N. 登録日 2020-06-16 公開日 2021-06-09 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.723 Å) 主引用文献 Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*. Angew.Chem.Int.Ed.Engl., 60, 2021
6PJV	Structure of Human Sonic Hedgehog in complex with Zinc and Magnesium 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Bonn-Breach, R.B, Jenkins, J.L, Wedekind, J.E. 登録日 2019-06-28 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design. Acta Crystallogr D Struct Biol, 75, 2019
6G6B	Crystal structure of a parallel six-helix coiled coil CC-Type2-LL-L17Q 分子名称: CC-Type2-LL-L17Q 著者 Rhys, G.G, Brady, R.L, Woolfson, D.N. 登録日 2018-04-01 公開日 2018-10-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nat Commun, 9, 2018
6G6F	Crystal structure of a parallel eight-helix coiled coil CC-Type2-LF 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CC-Type2-LF 著者 Rhys, G.G, Brady, R.L, Woolfson, D.N. 登録日 2018-04-01 公開日 2018-10-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nat Commun, 9, 2018
6G6I	MamM CTD W247A 分子名称: BETA-MERCAPTOETHANOL, Magnetosome protein MamM 著者 Barber-Zucker, S, Zarivach, R. 登録日 2018-04-01 公開日 2018-10-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Metal binding to the dynamic cytoplasmic domain of the cation diffusion facilitator (CDF) protein MamM induces a 'locked-in' configuration. Febs J., 286, 2019
7CB4	Crystal structures of of BlAsnase 分子名称: FORMIC ACID, GLYCEROL, L-asparaginase, ... 著者 Lu, F, Ran, T, Jiao, L, Wang, W. 登録日 2020-06-10 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structures of l-asparaginase from Bacillus licheniformis Reveal an Essential Residue for its Substrate Stereoselectivity. J.Agric.Food Chem., 69, 2021
6PBR	Catalytic domain of E.coli dihydrolipoamide succinyltransferase in I4 space group 分子名称: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, SODIUM ION 著者 Andi, B, Soares, A.S, Shi, W, Fuchs, M.R, McSweeney, S, Liu, Q. 登録日 2019-06-14 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form: a tale of a common protein crystallization contaminant. Acta Crystallogr.,Sect.F, 75, 2019
6MKA	Crystal structure of penicillin binding protein 5 (PBP5) from Enterococcus faecium in the open conformation 分子名称: SULFATE ION, penicillin binding protein 5 (PBP5) 著者 Moon, T.M, Lee, C, D'Andrea, E.D, Peti, W, Page, R. 登録日 2018-09-25 公開日 2018-10-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.698 Å) 主引用文献 The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
5DH1	Structure of the siderophore periplasmic binding protein from the fuscachelin gene cluster of Thermobifida fusca in P21 分子名称: siderophore periplasmic binding protein 著者 Li, K, Bruner, S.D. 登録日 2015-08-29 公開日 2015-11-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.842 Å) 主引用文献 Structure and functional analysis of the siderophore periplasmic binding protein from the fuscachelin gene cluster of Thermobifida fusca. Proteins, 84, 2016
8KH3	Crystal Structure of Kemp Eliminase HG3.17 in complexed with 5-cyanobenzotriazole 分子名称: 1H-benzotriazole-5-carbonitrile, Kemp Eliminase HG3.17, SULFATE ION 著者 Bunzel, A, Mori, T, Hilvert, D. 登録日 2023-08-21 公開日 2024-09-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Evolution of preorganized electric fields boosts catalysis in a designer enzyme To Be Published
6MRV	Sialidase26 co-crystallized with DANA 分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, Sialidase26 著者 Zaramela, L.S, Martino, C, Alisson-Silva, F, Rees, S.D, Diaz, S.L, Chuzel, L, Ganatra, M.B, Taron, C.H, Zuniga, C, Chang, G, Varki, A, Zengler, K. 登録日 2018-10-15 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. Nat Microbiol, 4, 2019
7C9B	Crystal structure of dipeptidase-E from Xenopus laevis 分子名称: Alpha-aspartyl dipeptidase, CALCIUM ION, SODIUM ION 著者 Kumar, A, Singh, R, Makde, R.D. 登録日 2020-06-05 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of aspartyl dipeptidase from Xenopus laevis revealed ligand binding induced loop ordering and catalytic triad assembly. Proteins, 90, 2022
6G6N	Crystal structure of the computationally designed Tako8 protein in C2 分子名称: Tako8 著者 Noguchi, H, Addy, C, Simoncini, D, Van Meervelt, L, Schiex, T, Zhang, K.Y.J, Tame, J.R.H, Voet, A.R.D. 登録日 2018-04-01 公開日 2018-11-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Computational design of symmetrical eight-bladed beta-propeller proteins. IUCrJ, 6, 2019

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