6PBJ

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with Gly190Pro mutation

Summary for 6PBJ

Entry DOI	10.2210/pdb6pbj/pdb
Descriptor	Phospho-2-dehydro-3-deoxyheptonate aldolase, PHOSPHATE ION, SULFATE ION, ... (8 entities in total)
Functional Keywords	dah7ps, allostery, shipmate pathway, tim barrel, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	103444.53
Authors	Jiao, W.,Fan, Y.,Blackmore, N.J.,Parker, E.J. (deposition date: 2019-06-13, release date: 2020-04-08, Last modification date: 2023-10-11)
Primary citation	Jiao, W.,Fan, Y.,Blackmore, N.J.,Parker, E.J. A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis . J.Biol.Chem., 295:6252-6262, 2020 Cited by PubMed: 32217694 DOI: 10.1074/jbc.RA120.012605 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation