6PJV

Structure of Human Sonic Hedgehog in complex with Zinc and Magnesium

Summary for 6PJV

Entry DOI	10.2210/pdb6pjv/pdb
Descriptor	Sonic hedgehog protein, DIMETHYL SULFOXIDE, GLYCEROL, ... (7 entities in total)
Functional Keywords	hedgehog proteins, signaling, zinc ions, magnesium ions, autocatalytic cleavage developmental, protein, holoprosencephaly, secreted, signaling protein, sonic hedgehog, shh, shh-n
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	19633.90
Authors	Bonn-Breach, R.B.,Jenkins, J.L.,Wedekind, J.E. (deposition date: 2019-06-28, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Bonn-Breach, R.,Gu, Y.,Jenkins, J.,Fasan, R.,Wedekind, J. Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design. Acta Crystallogr D Struct Biol, 75:969-979, 2019 Cited by PubMed: 31692471 DOI: 10.1107/S2059798319012890 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation