6PJV

Structure of Human Sonic Hedgehog in complex with Zinc and Magnesium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007267	biological_process	cell-cell signaling
A	0007275	biological_process	multicellular organism development

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue DMS A 201

Chain	Residue
A	GLN46
A	ASN50
A	PRO78
A	TYR80
A	GLY93
A	HOH428

---

site_id	AC2
Number of Residues	4
Details	binding site for residue DMS A 202

Chain	Residue
A	HOH424
A	GLU53
A	GLU176
A	HOH347

---

site_id	AC3
Number of Residues	2
Details	binding site for residue DMS A 203

Chain	Residue
A	PHE47
A	HOH424

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 204

Chain	Residue
A	GLN116
A	TRP117
A	MET160
A	HOH302
A	HOH303
A	HOH421

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 205

Chain	Residue
A	GLU90
A	GLU126
A	HOH307
A	HOH309
A	HOH315
A	HOH386

---

site_id	AC6
Number of Residues	6
Details	binding site for residue ZN A 206

Chain	Residue
A	HIS140
A	ASP147
A	GLU176
A	HIS182
A	HOH313
A	HOH319

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG A 207

Chain	Residue
A	HIS140
A	ASP147
A	GLU176
A	HIS182
A	HOH313
A	HOH319

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL A 208

Chain	Residue
A	ASN81
A	ASN107
A	HOH525

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CL A 209

Chain	Residue
A	LYS87
A	ARG123
A	HOH468
A	HOH495

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31555730","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RMG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---