6YA6

Minimal construct of Cdc7-Dbf4 bound to XL413

Summary for 6YA6

• Entry DOI: 10.2210/pdb6ya6/pdb
• Descriptor: Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase, Protein DBF4 homolog A, 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one, ... (9 entities in total)
• Functional Keywords: kinase, cdc7, dbf4, cell cycle, bivalent substrate, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 57926.87

Authors

Dick, S.D.,Cherepanov, P. (deposition date: 2020-03-11, release date: 2020-05-27, Last modification date: 2024-01-24)

• Primary citation: Dick, S.D.,Federico, S.,Hughes, S.M.,Pye, V.E.,O'Reilly, N.,Cherepanov, P.; Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.; Structure, 28:954-962.e4, 2020; PubMed: 32521228; DOI: 10.1016/j.str.2020.05.010

Experimental method

X-RAY DIFFRACTION (1.44 Å)