6YA6
Minimal construct of Cdc7-Dbf4 bound to XL413
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase | polymer | 359 | 40230.4 | 1 | UniProt (O00311) Pfam (PF00069) | Homo sapiens (Human) | huCdc7,huCdc7,huCdc7 |
| 2 | B (B) | Protein DBF4 homolog A | polymer | 144 | 17003.4 | 1 | UniProt (Q9UBU7) Pfam (PF07535) | Homo sapiens (Human) | Activator of S phase kinase,Chiffon homolog A,DBF4-type zinc finger-containing protein 1 |
| 3 | C (A) | 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one | non-polymer | 289.7 | 1 | Chemie (0SX) | |||
| 4 | D, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | F (A) | BORIC ACID | non-polymer | 61.8 | 1 | Chemie (BO3) | |||
| 7 | H (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | I (B) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 9 | J, K (A, B) | water | water | 18.0 | 464 | Chemie (HOH) |
Sequence modifications
A: 37 - 345 (UniProt: O00311)
A: 346 - 467 (UniProt: O00311)
A: 534 - 574 (UniProt: O00311)
B: 210 - 350 (UniProt: Q9UBU7)
| PDB | External Database | Details |
|---|---|---|
| Met 36 | - | initiating methionine |
A: 534 - 574 (UniProt: O00311)
| PDB | External Database | Details |
|---|---|---|
| Ala 468 | - | linker |
| Gly 469 | - | linker |
| Ala 470 | - | linker |
| Gly 471 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 207 | - | expression tag |
| Pro 208 | - | expression tag |
| Gly 209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57233.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 693.0 | |
| All* | Total formula weight | 57926.9 |
