7QXY
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 3 | 分子名称: | 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.478 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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6N6Y
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5UXN
| Type II DAH7PS from Pseudomonas aeruginosa with Tyr bound | 分子名称: | CHLORIDE ION, COBALT (II) ION, PHOSPHATE ION, ... | 著者 | Sterritt, O.W, Jameson, G.B, Parker, E.J. | 登録日 | 2017-02-23 | 公開日 | 2018-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux. Biochemistry, 57, 2018
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7WF8
| Crystal structure of mouse SNX25 RGS domain in space group P212121 | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Zhang, Y, Xu, J, Liu, J. | 登録日 | 2021-12-26 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins. J.Mol.Biol., 434, 2022
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6MYW
| Gluconobacter Ene-Reductase (GluER) mutant - T36A | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | 著者 | Garfinkle, S.E, Jeffrey, P, Hyster, T.K. | 登録日 | 2018-11-02 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.157 Å) | 主引用文献 | Photoexcitation of flavoenzymes enables a stereoselective radical cyclization. Science, 364, 2019
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5LIT
| Structure of the DNA duplex d(AAATTT)2 with the potential antiparasitic drug 6XV at 1.25 A resolution | 分子名称: | 4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzamide dihydrochloride, DNA (5'-D(*AP*AP*AP*TP*TP*T)-3'), MAGNESIUM ION | 著者 | Millan, C.R, Dardonville, C, de Koning, H.P, Saperas, N, Lourdes Campos, J. | 登録日 | 2016-07-15 | 公開日 | 2017-06-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast. Nucleic Acids Res., 45, 2017
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6N78
| Structure of the human JAK1 kinase domain with compound 21 | 分子名称: | GLYCEROL, N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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5DHL
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5LNL
| Crystal structure of Hsf 1608-1749 putative domain 1 | 分子名称: | Hsf | 著者 | Thomsen, M, Wright, J, Ridley, J, Goldman, A. | 登録日 | 2016-08-05 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | The crystal structure of PD1, a Haemophilus surface fibril domain. Acta Crystallogr F Struct Biol Commun, 73, 2017
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7OFY
| Crystal structure of SQ binding protein from Agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (SQGro) | 分子名称: | 1,2-ETHANEDIOL, Sulfoquinovosyl binding protein, [(2S,3S,4S,5R,6S)-6-[(2R)-2,3-bis(oxidanyl)propoxy]-3,4,5-tris(oxidanyl)oxan-2-yl]methanesulfonic acid | 著者 | Jarva, M.A, Sharma, M, Goddard-Borger, E.D, Davies, G.J. | 登録日 | 2021-05-05 | 公開日 | 2022-01-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria. Proc.Natl.Acad.Sci.USA, 119, 2022
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6N7A
| Structure of the human JAK1 kinase domain with compound 39 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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7QK9
| Crystal structure of the ALDH1A3-ATP complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, ... | 著者 | Castellvi, A, Farres, J. | 登録日 | 2021-12-17 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.782 Å) | 主引用文献 | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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5LL7
| Crystal structure of KPC-2 carbapenemase in complex with a phenyl boronic inhibitor. | 分子名称: | (~{E})-3-[2-(dihydroxyboranyl)phenyl]prop-2-enoic acid, 1,2-ETHANEDIOL, Beta-lactamase | 著者 | Vicario, M, Celenza, G, Bellio, P, Perilli, M.G, Tondi, D, Cendron, L. | 登録日 | 2016-07-26 | 公開日 | 2018-02-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance. Chemmedchem, 13, 2018
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7QFC
| Crystal structure of cytotoxin 13 from Naja naja, orthorhombic form | 分子名称: | Cytotoxin 13 | 著者 | Samygina, V.R, Dubova, K.M, Bourenkov, G, Utkin, Y.N, Dubovskii, P.V. | 登録日 | 2021-12-05 | 公開日 | 2022-04-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling. Toxins, 14, 2022
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8D41
| Crystal structure of the human COPB2 WD-domain in complex with OICR-6254 | 分子名称: | (1R,2R,3S,4S)-3-[4-(4-fluorophenyl)piperazine-1-carbonyl]bicyclo[2.2.1]heptane-2-carboxylic acid, Coatomer subunit beta', GLYCEROL, ... | 著者 | Zeng, H, Saraon, P, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2022-06-01 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the human COPB2 WD-domain in complex with OICR-6254 To Be Published
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5LQ5
| 1.46 A resolution structure of PhnD1 from Prochlorococcus marinus (MIT 9301) in complex with phosphite | 分子名称: | PHOSPHITE ION, Putative phosphonate binding protein for ABC transporter | 著者 | Bisson, C, Adams, N.B.P, Polyviou, D, Bibby, T.S, Hunter, C.N, Hitchcock, A. | 登録日 | 2016-08-16 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | The molecular basis of phosphite and hypophosphite recognition by ABC-transporters. Nat Commun, 8, 2017
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7QG5
| IRAK4 in complex with inhibitor | 分子名称: | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one, Interleukin-1 receptor-associated kinase 4 | 著者 | Xue, Y, Aagaard, A, Robb, G.R, Degorce, S.L. | 登録日 | 2021-12-07 | 公開日 | 2022-05-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg.Med.Chem., 63, 2022
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7OBN
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5LLI
| pVHL:EloB:EloC in complex with VH298 | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[(1-cyanocyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. | 登録日 | 2016-07-27 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition. Nat Commun, 7, 2016
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7QDJ
| Racemic structure of PK-10 and PK-11 | 分子名称: | GLYCEROL, MALONATE ION, PK-10+PK-11, ... | 著者 | Kumar, P, Paterson, N.G, Woolfson, D.N. | 登録日 | 2021-11-27 | 公開日 | 2022-04-27 | 最終更新日 | 2022-07-27 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | De novo design of discrete, stable 3 10 -helix peptide assemblies. Nature, 607, 2022
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7QRW
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5LMM
| Structure of E coli Hydrogenase Hyd-1 mutant E28Q | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CARBONMONOXIDE-(DICYANO) IRON, CHLORIDE ION, ... | 著者 | Carr, S.B, Phillips, S.E.V, Evans, R.M, Brooke, E.J, Armstrong, F.A. | 登録日 | 2016-08-01 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Kinetic consequences of re-engineering the outer shell "canopy" above the active site of a [NiFe]-hydrogenase. To Be Published
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6NV2
| 14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005 | 分子名称: | (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Wolter, M, Ottmann, C. | 登録日 | 2019-02-04 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
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8PBU
| Mutant K1482M of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate | 分子名称: | 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... | 著者 | del Cano-Ochoa, F, Ramon-Maiques, S. | 登録日 | 2023-06-09 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
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7WF6
| Crystal structure of SNX13 RGS domain | 分子名称: | CHLORIDE ION, Sorting nexin-13 | 著者 | Xu, J, Zhu, J, Liu, J. | 登録日 | 2021-12-26 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins. J.Mol.Biol., 434, 2022
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