5LL7

Crystal structure of KPC-2 carbapenemase in complex with a phenyl boronic inhibitor.

Summary for 5LL7

• Entry DOI: 10.2210/pdb5ll7/pdb
• Related: 5MGI
• Descriptor: Beta-lactamase, (~{E})-3-[2-(dihydroxyboranyl)phenyl]prop-2-enoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: carbapenemase, beta-lactamase, phenyl boronic inhibitor, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 28769.10

Authors

Vicario, M.,Celenza, G.,Bellio, P.,Perilli, M.G.,Tondi, D.,Cendron, L. (deposition date: 2016-07-26, release date: 2018-02-21, Last modification date: 2024-01-10)

• Primary citation: Celenza, G.,Vicario, M.,Bellio, P.,Linciano, P.,Perilli, M.,Oliver, A.,Blazquez, J.,Cendron, L.,Tondi, D.; Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance.; Chemmedchem, 13:713-724, 2018; PubMed: 29356380; DOI: 10.1002/cmdc.201700788

Experimental method

X-RAY DIFFRACTION (1.4 Å)