5MGI
Crystal structure of KPC-2 carbapenemase in complex with a phenyl boronic inhibitor.
Summary for 5MGI
| Entry DOI | 10.2210/pdb5mgi/pdb |
| Related | 5ll7 |
| Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, (~{E})-3-[2-(dihydroxyboranyl)phenyl]prop-2-enoic acid (3 entities in total) |
| Functional Keywords | carbapenemase, beta-lactamase, phenyl boronic inhibitor, hydrolase |
| Biological source | Klebsiella oxytoca |
| Total number of polymer chains | 1 |
| Total formula weight | 28184.48 |
| Authors | Vicario, M.,Celenza, G.,Bellio, P.,Perilli, M.G.,Tondi, D.,Cendron, L. (deposition date: 2016-11-21, release date: 2018-03-14, Last modification date: 2024-01-17) |
| Primary citation | Celenza, G.,Vicario, M.,Bellio, P.,Linciano, P.,Perilli, M.,Oliver, A.,Blazquez, J.,Cendron, L.,Tondi, D. Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance. Chemmedchem, 13:713-724, 2018 Cited by PubMed: 29356380DOI: 10.1002/cmdc.201700788 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report
