5LLI

pVHL:EloB:EloC in complex with VH298

Summary for 5LLI

Entry DOI	10.2210/pdb5lli/pdb
Descriptor	Transcription elongation factor B polypeptide 2, Transcription elongation factor B polypeptide 1, Von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	protein complex, ubiquitin ligase, hypoxia inducible factor, chemical probe, ligase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	12
Total formula weight	169043.63
Authors	Gadd, M.S.,Soares, P.,Galdeano, C.,Ciulli, A. (deposition date: 2016-07-27, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citation	Frost, J.,Galdeano, C.,Soares, P.,Gadd, M.S.,Grzes, K.M.,Ellis, L.,Epemolu, O.,Shimamura, S.,Bantscheff, M.,Grandi, P.,Read, K.D.,Cantrell, D.A.,Rocha, S.,Ciulli, A. Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition. Nat Commun, 7:13312-13312, 2016 Cited by PubMed: 27811928 DOI: 10.1038/ncomms13312 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation