6CEC
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![BU of 6cec by Molmil](/molmil-images/mine/6cec) | Crystal structure of fragment 3-(3-Methoxy-2-quinoxalinyl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain | 分子名称: | 3-(3-methoxyquinoxalin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... | 著者 | Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Franzoni, I, Ravichandran, M, Lautens, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-11 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
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6CEF
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![BU of 6cef by Molmil](/molmil-images/mine/6cef) | Crystal structure of fragment 3-(1,3-Benzothiazol-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain | 分子名称: | 3-(1,3-benzothiazol-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... | 著者 | Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-11 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
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6LQO
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![BU of 6lqo by Molmil](/molmil-images/mine/6lqo) | EBV tegument protein BBRF2/BSRF1 complex | 分子名称: | ACETATE ION, Cytoplasmic envelopment protein 1, GLYCEROL, ... | 著者 | He, H.P, Luo, M, Cao, Y.L, Gao, S. | 登録日 | 2020-01-14 | 公開日 | 2020-10-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.0911262 Å) | 主引用文献 | Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun, 11, 2020
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6LY9
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![BU of 6ly9 by Molmil](/molmil-images/mine/6ly9) | The membrane-embedded Vo domain of V/A-ATPase from Thermus thermophilus | 分子名称: | V-type ATP synthase subunit C, V-type ATP synthase subunit E, V-type ATP synthase subunit I, ... | 著者 | Kishikawa, J, Nakanishi, A, Furuta, A, Kato, T, Namba, K, Tamakoshi, M, Mitsuoka, K, Yokoyama, K. | 登録日 | 2020-02-13 | 公開日 | 2020-09-09 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | 主引用文献 | Mechanical inhibition of isolated V o from V/A-ATPase for proton conductance. Elife, 9, 2020
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4DV9
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![BU of 4dv9 by Molmil](/molmil-images/mine/4dv9) | Crystal structure of BACE1 with its inhibitor | 分子名称: | Beta-secretase 1, METHYL (2S)-1-[(2R,5S,8S,12S,13S,16S,19S,22S)-16-(3-AMINO-3-OXOPROPYL)-2,13-DIBENZYL-12,22-DIHYDROXY-3,5,17-TRIMETHYL-8-(2-METHYLPROPYL)-4,7,10,15,18,21-HEXAOXO-19-(PROPAN-2-YL)-3,6,9,14,17,20-HEXAAZATRICOSAN-1-OYL]PYRROLIDINE-2-CARBOXYLATE (NON-PREFERRED NAME), SULFATE ION | 著者 | Xu, Y.C, Chen, W.Y, Li, L, Chen, T.T. | 登録日 | 2012-02-23 | 公開日 | 2013-01-16 | 最終更新日 | 2021-09-15 | 実験手法 | X-RAY DIFFRACTION (2.076 Å) | 主引用文献 | Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem., 55, 2012
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1R9U
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![BU of 1r9u by Molmil](/molmil-images/mine/1r9u) | Refined structure of peptaibol zervamicin IIB in methanol solution from trans-hydrogen bond J couplings | 分子名称: | ZERVAMICIN IIB | 著者 | Shenkarev, Z.O, Balashova, T.A, Yakimenko, Z.A, Ovchinnikova, T.V, Arseniev, A.S. | 登録日 | 2003-10-31 | 公開日 | 2004-11-09 | 最終更新日 | 2018-10-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Biosynthetic Uniform 13C,15N-Labelling of Zervamicin Iib. Complete 13C and 15N NMR Assignment. J.Pept.Sci., 9, 2003
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6M8O
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6LUV
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![BU of 6luv by Molmil](/molmil-images/mine/6luv) | |
6M91
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![BU of 6m91 by Molmil](/molmil-images/mine/6m91) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex | 分子名称: | 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid, CHLORIDE ION, Catenin beta-1, ... | 著者 | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. | 登録日 | 2018-08-22 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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6LV8
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4PQQ
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![BU of 4pqq by Molmil](/molmil-images/mine/4pqq) | The crystal structure of discoidin domain from muskelin | 分子名称: | Muskelin, PHOSPHATE ION, TETRAETHYLENE GLYCOL | 著者 | Kim, K.-H, Hong, S.K, Kim, E.E. | 登録日 | 2014-03-04 | 公開日 | 2014-11-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of mouse muskelin discoidin domain and biochemical characterization of its self-association. Acta Crystallogr.,Sect.D, 70, 2014
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6LV4
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6M4P
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![BU of 6m4p by Molmil](/molmil-images/mine/6m4p) | Cytochrome P450 monooxygenase StvP2 substrate-bound structure | 分子名称: | 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | 登録日 | 2020-03-08 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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3IXJ
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![BU of 3ixj by Molmil](/molmil-images/mine/3ixj) | Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor | 分子名称: | Beta-secretase 1, N-[4-(1-BENZYLCARBAMOYL-2-METHYL-PROPYLCARBAMOYL)-1-(3,5-DIFLUORO-PHENOXYMETHYL)-2-HYDROXY-4-METHOXY-BUTYL]-5-(METHANESULFONYL-METHYL-AMINO)-N'-(1-PHENYLETHYL)-ISOPHTHALAMIDE, SULFATE ION | 著者 | Borkakoti, N, Lindberg, J, Nystrom, S. | 登録日 | 2009-09-04 | 公開日 | 2010-03-02 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design and Synthesis of Potent and Selective BACE-1 Inhibitors. J.Med.Chem., 53, 2010
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8XBW
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![BU of 8xbw by Molmil](/molmil-images/mine/8xbw) | The cryo-EM structure of the RAD51 N-terminal lobe domain bound to the histone H4 tail of the nucleosome | 分子名称: | DNA (5'-D(P*AP*CP*CP*GP*CP*TP*TP*AP*AP*AP*CP*GP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*GP*CP*GP*TP*TP*TP*AP*AP*GP*CP*GP*GP*T)-3'), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-12-07 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8XBU
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![BU of 8xbu by Molmil](/molmil-images/mine/8xbu) | The cryo-EM structure of the decameric RAD51 ring bound to the nucleosome with the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-12-07 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.24 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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6M93
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![BU of 6m93 by Molmil](/molmil-images/mine/6m93) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex | 分子名称: | 2-oxo-N-[3-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide, Catenin beta-1, F-box/WD repeat-containing protein 1A, ... | 著者 | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Lee, S.J. | 登録日 | 2018-08-22 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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6CB1
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![BU of 6cb1 by Molmil](/molmil-images/mine/6cb1) | Yeast nucleolar pre-60S ribosomal subunit (state 3) | 分子名称: | 35S pre-ribosomal RNA miscRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... | 著者 | Sanghai, Z.A, Miller, L, Barandun, J, Hunziker, M, Chaker-Margot, M, Klinge, S. | 登録日 | 2018-02-01 | 公開日 | 2018-03-14 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature, 556, 2018
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8XBT
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![BU of 8xbt by Molmil](/molmil-images/mine/8xbt) | The cryo-EM structure of the octameric RAD51 ring bound to the nucleosome with the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-12-07 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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6NY3
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![BU of 6ny3 by Molmil](/molmil-images/mine/6ny3) | CasX ternary complex with 30bp target DNA | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | 登録日 | 2019-02-10 | 公開日 | 2019-02-27 | 最終更新日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature, 566, 2019
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4EU1
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6NN9
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![BU of 6nn9 by Molmil](/molmil-images/mine/6nn9) | REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ... | 著者 | Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M. | 登録日 | 1991-03-28 | 公開日 | 1992-07-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. J.Mol.Biol., 221, 1991
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6NRA
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![BU of 6nra by Molmil](/molmil-images/mine/6nra) | hTRiC-hPFD Class1 (No PFD) | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | 登録日 | 2019-01-23 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Cell, 177, 2019
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6NU3
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![BU of 6nu3 by Molmil](/molmil-images/mine/6nu3) | Structural insights into unique features of the human mitochondrial ribosome recycling | 分子名称: | 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ... | 著者 | Sharma, M.R, Koripella, R.K, Agrawal, R.K. | 登録日 | 2019-01-30 | 公開日 | 2019-04-17 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural insights into unique features of the human mitochondrial ribosome recycling. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NSU
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![BU of 6nsu by Molmil](/molmil-images/mine/6nsu) | Crystallographic Capture of Quinolinate Synthase (NadA) from Pyrococcus horikoshii in its Substrates and Product-Bound States | 分子名称: | DIDEHYDROASPARTATE, IRON/SULFUR CLUSTER, Quinolinate synthase A | 著者 | Esakova, O.A, Grove, T.L, Silakov, A, Yennawar, N.H, Booker, S.J. | 登録日 | 2019-01-25 | 公開日 | 2019-08-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase. J.Am.Chem.Soc., 141, 2019
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