6M93
Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex
Summary for 6M93
Entry DOI | 10.2210/pdb6m93/pdb |
Descriptor | F-box/WD repeat-containing protein 1A, S-phase kinase-associated protein 1, Catenin beta-1, ... (6 entities in total) |
Functional Keywords | ubiquitin molecular glue enhancer, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 69868.10 |
Authors | Simonetta, K.R.,Clifton, M.C.,Walter, R.L.,Ranieri, G.M.,Lee, S.J. (deposition date: 2018-08-22, release date: 2019-04-03, Last modification date: 2019-04-10) |
Primary citation | Simonetta, K.R.,Taygerly, J.,Boyle, K.,Basham, S.E.,Padovani, C.,Lou, Y.,Cummins, T.J.,Yung, S.L.,von Soly, S.K.,Kayser, F.,Kuriyan, J.,Rape, M.,Cardozo, M.,Gallop, M.A.,Bence, N.F.,Barsanti, P.A.,Saha, A. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10:1402-1402, 2019 Cited by PubMed: 30926793DOI: 10.1038/s41467-019-09358-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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