Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue J8Y A 601 |
| Chain | Residue |
| A | ARG330 |
| A | ALA434 |
| A | SER448 |
| C | ILE35 |
| C | HIS36 |
| C | SER37 |
| A | LEU340 |
| A | ASN341 |
| A | THR342 |
| A | ASN394 |
| A | GLY408 |
| A | ARG431 |
| A | GLY432 |
| A | ILE433 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 602 |
| Chain | Residue |
| A | ARG477 |
| A | PHE478 |
| A | GLN526 |
| A | PHE527 |
| A | HOH707 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. IITGssDsTVRVWDV |
| Chain | Residue | Details |
| A | ILE320-VAL334 | |
| A | MET360-MET374 | |
| A | ILE403-THR417 | |
| A | VAL443-ILE457 | |
| A | ILE483-LEU497 | |
| A | ILE532-PHE546 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | Domain: {"description":"F-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00080","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 1"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 2"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 3"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 4"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 5"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"WD 6"} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 38 |
| Details | Region: {"description":"Required for down-regulation of SNAI1"} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by GSK3-beta and HIPK2","evidences":[{"source":"PubMed","id":"20307497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25169422","evidenceCode":"ECO:0000269"}]} |
