5XTI
 
 | | Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 | | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, Acyl carrier protein, ... | | 著者 | Gu, J, Wu, M, Yang, M. | | 登録日 | 2017-06-19 | | 公開日 | 2017-09-13 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (17.4 Å) | | 主引用文献 | Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Cell, 170, 2017
|
|
7PBC
 | | Crystal structure of engineered TCR (796) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide | | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | | 著者 | Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J. | | 登録日 | 2021-08-02 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
|
|
6D0I
 | | ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS. L48M ParT, SeMet-substituted complex. | | 分子名称: | GLYCEROL, ParS: COG5642 (DUF2384) antitoxin fragment, ParT: COG5654 (RES domain) toxin | | 著者 | Piscotta, F.J, Jeffrey, P.D, Link, A.J. | | 登録日 | 2018-04-10 | | 公開日 | 2019-01-09 | | 最終更新日 | 2019-01-23 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
6NZF
 | |
6Y1H
 | |
6D0R
 | |
6VXE
 | |
6Y9X
 | | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,7) | | 分子名称: | Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2020-03-10 | | 公開日 | 2020-08-19 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
|
|
6OCD
 | | Ricin A chain bound to VHH antibody V6D4 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-22 | | 公開日 | 2020-04-01 | | 最終更新日 | 2020-10-14 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
|
|
6ODG
 | | SVQIVY, Crystal Structure of a tau protein fragment | | 分子名称: | Microtubule-associated protein tau | | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | | 登録日 | 2019-03-26 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J.Biol.Chem., 294, 2019
|
|
6Y7Y
 | | Fragments KCL_771 and KCL_802 in complex with MAP kinase p38-alpha | | 分子名称: | (2-azanyl-2-adamantyl)methanol, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridine-3-sulfonamide, ... | | 著者 | De Nicola, G.F, Nichols, C.E. | | 登録日 | 2020-03-02 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
|
|
7R1Y
 | |
6Y7W
 | | Fragment KCL_1337 in complex with MAP kinase p38-alpha | | 分子名称: | (2~{R})-~{N}-[(2-azanyl-2-adamantyl)methyl]-4-[6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridin-3-yl]sulfonyl-2-methyl-morpholine-2-carboxamide, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ... | | 著者 | De Nicola, G.F, Nichols, C.E. | | 登録日 | 2020-03-02 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
|
|
7R5K
 | | Human nuclear pore complex (constricted) | | 分子名称: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | | 著者 | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | | 登録日 | 2022-02-10 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Science, 376, 2022
|
|
8ERT
 | | NLRP3 PYD filament | | 分子名称: | NACHT, LRR and PYD domains-containing protein 3 | | 著者 | Wu, H, Xiao, L. | | 登録日 | 2022-10-12 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the active NLRP3 inflammasome disc.
Nature, 613, 2023
|
|
6Y9Y
 | | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-7,13) | | 分子名称: | Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2020-03-10 | | 公開日 | 2020-08-19 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
|
|
8EJ4
 | |
6VZY
 | |
6YCU
 | | Fragment KCL_K777 in complex with MAP kinase p38-alpha | | 分子名称: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 4-[2,5-bis(oxidanylidene)pyrrol-1-yl]-~{N}-propyl-benzenesulfonamide, CALCIUM ION, ... | | 著者 | De Nicola, G.F, Nichols, C.E. | | 登録日 | 2020-03-19 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
|
|
8EHG
 | | Rabbit muscle aldolase determined using single-particle cryo-EM with Apollo camera. | | 分子名称: | Fructose-bisphosphate aldolase A | | 著者 | Peng, R, Fu, X, Mendez, J.H, Randolph, P.H, Bammes, B, Stagg, S.M. | | 登録日 | 2022-09-14 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.24 Å) | | 主引用文献 | Characterizing the resolution and throughput of the Apollo direct electron detector.
J Struct Biol X, 7, 2023
|
|
4RWO
 | | Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position | | 分子名称: | 2'-5'-oligoadenylate synthase 1, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... | | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | | 登録日 | 2014-12-05 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Structure, 23, 2015
|
|
6O2S
 | | Deacetylated Microtubules | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Eshun-Wilson, L, Zhang, R, Portran, D, Nachury, M.V, Toso, D, Lohr, T, Vendruscolo, M, Bonomi, M, Fraser, J.S, Nogales, E. | | 登録日 | 2019-02-24 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Effects of alpha-tubulin acetylation on microtubule structure and stability.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
7PMU
 | | Crystal structure of native Iripin-8 | | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Serpin-8, ... | | 著者 | Polderdijk, S, Kotal, J, Chmelar, J, Huntington, J.A. | | 登録日 | 2021-09-02 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.
Int J Mol Sci, 22, 2021
|
|
7PMW
 | | HsPepT1 bound to Ala-Phe in the outward facing occluded conformation | | 分子名称: | ALA-PHE, Solute carrier family 15 member 1 | | 著者 | Killer, M, Wald, J, Pieprzyk, J, Marlovits, T.C, Loew, C. | | 登録日 | 2021-09-03 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Sci Adv, 7, 2021
|
|
6O2T
 | | Acetylated Microtubules | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Eshun-Wilson, L, Zhang, R, Portran, D, Nachury, M.V, Toso, D, Lohr, T, Vendruscolo, M, Bonomi, M, Fraser, J.S, Nogales, E. | | 登録日 | 2019-02-24 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Effects of alpha-tubulin acetylation on microtubule structure and stability.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
