8BW9
 
 | | Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP | | 分子名称: | Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ... | | 著者 | Maisonneuve, P, Fronzes, R, Sicheri, F. | | 登録日 | 2022-12-06 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
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6Z1H
 | | Ancestral glycosidase (family 1) | | 分子名称: | ANCESTRAL RECONSTRUCTED GLYCOSIDASE, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Gavira, J.A, Risso, V.A, Sanchez-Ruiz, J.M, Gamiz-Arco, G, Gutierrez-Rus, L, Ibarra-Molero, B, Hoshino, Y, Petrovic, D, Romero-Rivera, A, Seelig, B, Kamerlin, S.C.L, Gaucher, E.A. | | 登録日 | 2020-05-13 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
Nat Commun, 12, 2021
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7RTU
 | | Cryo-EM structure of a TTYH2 trans-dimer | | 分子名称: | Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Li, B, Brohawn, S.G, Hoel, C.M. | | 登録日 | 2021-08-15 | | 公開日 | 2021-08-25 | | 最終更新日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | | 主引用文献 | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization.
Nat Commun, 12, 2021
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7RTW
 | | Cryo-EM structure of a TTYH3 cis-dimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Li, B, Brohawn, S.G, Hoel, C.M. | | 登録日 | 2021-08-15 | | 公開日 | 2021-08-25 | | 最終更新日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization.
Nat Commun, 12, 2021
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7RTT
 | | Cryo-EM structure of a TTYH2 cis-dimer | | 分子名称: | CALCIUM ION, Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Li, B, Brohawn, S.G, Hoel, C.M. | | 登録日 | 2021-08-15 | | 公開日 | 2021-08-25 | | 最終更新日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization.
Nat Commun, 12, 2021
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6ZCM
 | | Crystal structure of YTHDC1 with compound DHU_DC1_180 | | 分子名称: | 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 | | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | | 登録日 | 2020-06-11 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
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6ZD3
 | | Crystal structure of YTHDC1 M438A mutant | | 分子名称: | DI(HYDROXYETHYL)ETHER, SULFATE ION, YTH domain containing 1 | | 著者 | Bedi, R.K, Li, Y, Caflisch, A. | | 登録日 | 2020-06-13 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
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6D03
 | | Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; one molecule of parasite ligand. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(2-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H. | | 登録日 | 2018-04-10 | | 公開日 | 2018-06-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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8EMB
 | | X-ray crystal structure of Thermosynechococcus elongatus Si3 domain of RNA polymerase RpoC2 subunit | | 分子名称: | DNA-directed RNA polymerase subunit beta' | | 著者 | Murakami, K.S, Imashimizu, M, Qayyum, M.Z, Vishwakarma, R.K, Yuzenkova, Y. | | 登録日 | 2022-09-27 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | | 主引用文献 | Structure and function of the Si3 insertion integrated into the trigger loop/helix of cyanobacterial RNA polymerase.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7RTV
 | | Cryo-EM structure of monomeric TTYH2 | | 分子名称: | Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Li, B, Brohawn, S.G, Hoel, C.M. | | 登録日 | 2021-08-15 | | 公開日 | 2021-09-22 | | 最終更新日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization.
Nat Commun, 12, 2021
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8D2N
 | | Structure of Acidothermus cellulolyticus Cas9 ternary complex (Pre-cleavage) | | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ... | | 著者 | Rai, J, Das, A, Li, H. | | 登録日 | 2022-05-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
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8D2P
 | | Structure of Acidothermus cellulolyticus Cas9 ternary complex (Target bound) | | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA target strand (5'-D(P*CP*CP*AP*GP*GP*AP*TP*CP*TP*TP*GP*CP*CP*AP*TP*CP*CP*TP*AP*CP*CP*TP*CP*T)-3'), ... | | 著者 | Rai, J, Das, A, Li, H. | | 登録日 | 2022-05-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
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8D2K
 | | Structure of Acidothermus cellulolyticus Cas9 ternary complex (Cleavage Intermediate 2) | | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*GP*A)-3'), ... | | 著者 | Rai, J, Das, A, Li, H. | | 登録日 | 2022-05-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
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8D2O
 | | Structure of Acidothermus cellulolyticus Cas9 ternary complex (Post-cleavage 2) | | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ... | | 著者 | Rai, J, Das, A, Li, H. | | 登録日 | 2022-05-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
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8D2L
 | | Structure of Acidothermus cellulolyticus Cas9 ternary complex (Cleavage Intermediate 1) | | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*GP*A)-3'), ... | | 著者 | Rai, J, Das, A, Li, H. | | 登録日 | 2022-05-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.21 Å) | | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
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8DHU
 | | Crystal structure of LARP-DM15 from Drosophila melanogaster bound to m7GpppC | | 分子名称: | La-related protein 1, MAGNESIUM ION, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate | | 著者 | Nguyen, E, Berman, A.J. | | 登録日 | 2022-06-28 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | | 主引用文献 | Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution.
Plos One, 19, 2024
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8D2Q
 | | Structure of Acidothermus cellulolyticus Cas9 ternary complex (Post-cleavage 1) | | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ... | | 著者 | Rai, J, Das, A, Li, H. | | 登録日 | 2022-05-30 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
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7KE1
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8DIO
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7KET
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7KPT
 | | Crystal structure of CtdE in complex with FAD and substrate 4 | | 分子名称: | (6aR,7aS,11S,13aS)-6,6,11-trimethyl-4-(3-methylbut-2-en-1-yl)-6,6a,7,8,9,10,11,14-octahydro-5H,13H-13a,7a-(epiminomethano)quinolizino[2,3-b]carbazol-16-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Zhao, B, Hu, L. | | 登録日 | 2020-11-12 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins.
Nat Commun, 12, 2021
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7KPQ
 | | Crystal structure of CtdE in complex with FAD | | 分子名称: | FAD-dependent monooxygenase CtdE, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Zhao, B, Hu, L. | | 登録日 | 2020-11-12 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins.
Nat Commun, 12, 2021
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7L6Q
 | | Unliganded ELIC in styrene-maleic-acid nanodiscs at 2.5-Angstrom resolution | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CARDIOLIPIN, Gamma-aminobutyric-acid receptor subunit beta-1 | | 著者 | Grosman, C, Kumar, P. | | 登録日 | 2020-12-23 | | 公開日 | 2021-06-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structure and function at the lipid-protein interface of a pentameric ligand-gated ion channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7KUF
 | | Transcription activation subcomplex with WhiB7 bound to SigmaAr4-RNAP Beta flap tip chimera and DNA | | 分子名称: | DNA (5'-D(*CP*AP*GP*AP*AP*AP*AP*TP*CP*GP*GP*TP*TP*GP*TP*GP*GP*T)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*AP*AP*CP*CP*GP*AP*TP*TP*TP*TP*CP*T)-3'), IRON/SULFUR CLUSTER, ... | | 著者 | Wan, T, Horova, M, Beltran, D.G, Li, S.R, Zhang, L.M. | | 登録日 | 2020-11-24 | | 公開日 | 2021-06-30 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis.
Mol.Cell, 81, 2021
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7KUG
 | | Fe-S cluster-bound transcription activator WhiB7 in complex with the SigmaAr4-RNAP Beta flap tip chimera | | 分子名称: | IRON/SULFUR CLUSTER, Probable transcriptional regulator WhiB7, RNA polymerase sigma factor, ... | | 著者 | Wan, T, Horova, M, Beltran, D.G, Li, S.R, Zhang, L.M. | | 登録日 | 2020-11-24 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis.
Mol.Cell, 81, 2021
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