6Z1H

Ancestral glycosidase (family 1)

Summary for 6Z1H

Entry DOI	10.2210/pdb6z1h/pdb
Related	6Z1M
Descriptor	ANCESTRAL RECONSTRUCTED GLYCOSIDASE, Residues 249 to 266 of chain A and 246 to 258 of chain B could not be identified and has been included as UNK in chain C and D, respectively., GLYCEROL, ... (7 entities in total)
Functional Keywords	ancestral reconstructed, glycosidase, family 1, hydrolase
Biological source	synthetic construct More
Total number of polymer chains	4
Total formula weight	108235.84
Authors	Gavira, J.A.,Risso, V.A.,Sanchez-Ruiz, J.M.,Gamiz-Arco, G.,Gutierrez-Rus, L.,Ibarra-Molero, B.,Hoshino, Y.,Petrovic, D.,Romero-Rivera, A.,Seelig, B.,Kamerlin, S.C.L.,Gaucher, E.A. (deposition date: 2020-05-13, release date: 2020-07-22, Last modification date: 2024-01-24)
Primary citation	Gamiz-Arco, G.,Gutierrez-Rus, L.I.,Risso, V.A.,Ibarra-Molero, B.,Hoshino, Y.,Petrovic, D.,Justicia, J.,Cuerva, J.M.,Romero-Rivera, A.,Seelig, B.,Gavira, J.A.,Kamerlin, S.C.L.,Gaucher, E.A.,Sanchez-Ruiz, J.M. Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase. Nat Commun, 12:380-380, 2021 Cited by PubMed: 33452262 DOI: 10.1038/s41467-020-20630-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation