1GVL
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![BU of 1gvl by Molmil](/molmil-images/mine/1gvl) | Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin | 分子名称: | KALLIKREIN 6 | 著者 | Gomis-Ruth, F.X, Bayes, A, Sotiropoulou, G, Pampalakis, G, Tsetsenis, T, Villegas, V, Aviles, F.X, Coll, M. | 登録日 | 2002-02-14 | 公開日 | 2002-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Structure of Human Prokallikrein 6 Reveals a Novel Activation Mechanism for the Kallikrein Family. J.Biol.Chem., 277, 2002
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1CVW
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![BU of 1cvw by Molmil](/molmil-images/mine/1cvw) | Crystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA) | 分子名称: | CALCIUM ION, COAGULATION FACTOR VIIA (HEAVY CHAIN) (DES-GLA), COAGULATION FACTOR VIIA (LIGHT CHAIN) (DES-GLA), ... | 著者 | Kemball-Cook, G, Johnson, D.J.D, Tuddenham, E.G.D, Harlos, K. | 登録日 | 1999-08-24 | 公開日 | 1999-08-31 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla). J.Struct.Biol., 127, 1999
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3U1J
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![BU of 3u1j by Molmil](/molmil-images/mine/3u1j) | Aprotinin bound to Dengue virus protease | 分子名称: | Pancreatic trypsin inhibitor, Serine protease NS3, Serine protease subunit NS2B | 著者 | Noble, C.G. | 登録日 | 2011-09-30 | 公開日 | 2011-11-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Ligand-bound structures of the dengue virus protease reveal the active conformation J.Virol., 86, 2012
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3WNY
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1ELV
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![BU of 1elv by Molmil](/molmil-images/mine/1elv) | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE | 分子名称: | 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C1S COMPONENT, ... | 著者 | Gaboriaud, C, Rossi, V, Bally, I, Arlaud, G, Fontecilla-Camps, J.-C. | 登録日 | 2000-03-14 | 公開日 | 2001-03-14 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle. EMBO J., 19, 2000
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1Q3X
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![BU of 1q3x by Molmil](/molmil-images/mine/1q3x) | Crystal structure of the catalytic region of human MASP-2 | 分子名称: | GLYCEROL, Mannan-binding lectin serine protease 2, SODIUM ION | 著者 | Harmat, V, Gal, P, Kardos, J, Szilagyi, K, Ambrus, G, Naray-Szabo, G, Zavodszky, P. | 登録日 | 2003-08-01 | 公開日 | 2004-08-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions J.Mol.Biol., 342, 2004
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3N43
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![BU of 3n43 by Molmil](/molmil-images/mine/3n43) | Crystal structures of the mature envelope glycoprotein complex (trypsin cleavage) of Chikungunya virus. | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Voss, J, Vaney, M.C, Duquerroy, S, Rey, F.A. | 登録日 | 2010-05-21 | 公開日 | 2010-12-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography. Nature, 468, 2010
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1EAX
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![BU of 1eax by Molmil](/molmil-images/mine/1eax) | Crystal structure of MTSP1 (matriptase) | 分子名称: | BENZAMIDINE, SULFATE ION, SUPPRESSOR OF TUMORIGENICITY 14 | 著者 | Friedrich, R, Bode, W. | 登録日 | 2001-07-17 | 公開日 | 2002-01-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Catalytic Domain Structures of Mt-Sp1/Matriptase, a Matrix-Degrading Transmembrane Serine Proteinase. J.Biol.Chem., 277, 2002
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1C5V
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![BU of 1c5v by Molmil](/molmil-images/mine/1c5v) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | CALCIUM ION, MAGNESIUM ION, PROTEIN (TRYPSIN) | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1C5Q
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![BU of 1c5q by Molmil](/molmil-images/mine/1c5q) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE, CALCIUM ION, CHLORIDE ION, ... | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1C5P
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![BU of 1c5p by Molmil](/molmil-images/mine/1c5p) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | BENZAMIDINE, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1C5T
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![BU of 1c5t by Molmil](/molmil-images/mine/1c5t) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | CALCIUM ION, PROTEIN (TRYPSIN), THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1C5S
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![BU of 1c5s by Molmil](/molmil-images/mine/1c5s) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | BENZO[B]THIOPHENE-2-CARBOXAMIDINE, CALCIUM ION, PROTEIN (TRYPSIN), ... | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1C5U
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![BU of 1c5u by Molmil](/molmil-images/mine/1c5u) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | CALCIUM ION, MAGNESIUM ION, PROTEIN (TRYPSIN), ... | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1C5R
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![BU of 1c5r by Molmil](/molmil-images/mine/1c5r) | STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE, CALCIUM ION, CITRATE ANION, ... | 著者 | Katz, B.A, Mackman, R, Luong, C, Radika, K, Martelli, A, Sprengeler, P.A, Wang, J, Chan, H, Wong, L. | 登録日 | 1999-12-22 | 公開日 | 2000-12-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem.Biol., 7, 2000
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1CGH
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![BU of 1cgh by Molmil](/molmil-images/mine/1cgh) | Human cathepsin G | 分子名称: | CATHEPSIN G, N-(3-carboxypropanoyl)-L-valyl-N-{(1R)-1-[(S)-hydroxy(oxido)phosphanyl]-2-phenylethyl}-L-prolinamide | 著者 | Hof, P, Bode, W. | 登録日 | 1996-06-26 | 公開日 | 1997-07-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J., 15, 1996
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3LDI
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![BU of 3ldi by Molmil](/molmil-images/mine/3ldi) | Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding | 分子名称: | GLYCEROL, MERCURY (II) ION, Pancreatic trypsin inhibitor, ... | 著者 | Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. | 登録日 | 2010-01-13 | 公開日 | 2010-06-23 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding Biochem.Biophys.Res.Commun., 397, 2010
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3LDJ
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![BU of 3ldj by Molmil](/molmil-images/mine/3ldj) | Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, Pancreatic trypsin inhibitor | 著者 | Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. | 登録日 | 2010-01-13 | 公開日 | 2010-09-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding. Biochem.Biophys.Res.Commun., 2010
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3LDM
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1PBI
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1AZZ
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![BU of 1azz by Molmil](/molmil-images/mine/1azz) | |
1FAK
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![BU of 1fak by Molmil](/molmil-images/mine/1fak) | HUMAN TISSUE FACTOR COMPLEXED WITH COAGULATION FACTOR VIIA INHIBITED WITH A BPTI-MUTANT | 分子名称: | CALCIUM ION, PROTEIN (5L15), PROTEIN (BLOOD COAGULATION FACTOR VIIA), ... | 著者 | Zhang, E, St Charles, R, Tulinsky, A. | 登録日 | 1998-12-28 | 公開日 | 1999-12-03 | 最終更新日 | 2023-05-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant. J.Mol.Biol., 285, 1999
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2A4G
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![BU of 2a4g by Molmil](/molmil-images/mine/2a4g) | Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound | 分子名称: | ({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC ACID ISOBUTYL ESTER, NS3 protease/helicase, NS4a peptide, ... | 著者 | Arasappan, A, Njoroge, F.G, Chan, T.Y, Bennett, F, Bogen, S.L, Chen, K, Gu, H, Hong, L, Jao, E, Liu, Y.T, Lovey, R.G, Parekh, T, Pike, R.E, Pinto, P, Santhanam, B, Venkatraman, S, Vaccaro, H, Wang, H, Yang, X, Zhu, Z, Mckittrick, B, Saksena, A.K, Girijavallabhan, V, Pichardo, J, Butkiewicz, N, Ingram, R, Malcolm, B, Prongay, A.J, Yao, N, Marten, B, Madison, V, Kemp, S, Levy, O, Lim-Wilby, M, Tamura, S, Ganguly, A.K. | 登録日 | 2005-06-28 | 公開日 | 2006-07-04 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency. Bioorg.Med.Chem.Lett., 15, 2005
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1H8I
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![BU of 1h8i by Molmil](/molmil-images/mine/1h8i) | X-ray crystal structure of human alpha-thrombin with a tripeptide phosphonate inhibitor. | 分子名称: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-[(1S)-4-methoxy-1-phosphonobutyl]-L-prolinamide, THROMBIN | 著者 | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | 登録日 | 2001-02-08 | 公開日 | 2001-03-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
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1H8D
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![BU of 1h8d by Molmil](/molmil-images/mine/1h8d) | X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor. | 分子名称: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide, THROMBIN | 著者 | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | 登録日 | 2001-02-01 | 公開日 | 2001-02-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
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