7QQT
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![BU of 7qqt by Molmil](/molmil-images/mine/7qqt) | SpCas9 bound to FANCF off-target1 DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target1 non-target strand, FANCF off-target1 target strand, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-01-10 | 公開日 | 2022-10-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR8
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7QQP
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7QQS
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![BU of 7qqs by Molmil](/molmil-images/mine/7qqs) | SpCas9 bound to FANCF on-target DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF on-target non-target strand, FANCF on-target target strand, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-01-10 | 公開日 | 2022-10-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7C7O
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![BU of 7c7o by Molmil](/molmil-images/mine/7c7o) | Crystal structure of E.coli DNA gyrase B in complex with 6-fluoro-8-(methylamino)-2-oxo-1,2-dihydroquinoline derivative | 分子名称: | 4-[[4-(3-azanylpropylamino)-6-fluoranyl-8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid, DNA gyrase subunit B | 著者 | Kamitani, M, Mima, M, Takeuchi, T, Ushiyama, F. | 登録日 | 2020-05-26 | 公開日 | 2020-10-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg.Med.Chem., 28, 2020
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7C7N
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1TW8
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![BU of 1tw8 by Molmil](/molmil-images/mine/1tw8) | HincII bound to Ca2+ and cognate DNA GTCGAC | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', CALCIUM ION, Hinc II endonuclease, ... | 著者 | Etzkorn, C, Horton, N.C. | 登録日 | 2004-06-30 | 公開日 | 2004-08-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Ca2+ binding in the active site of HincII: implications for the catalytic mechanism Biochemistry, 43, 2004
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1Z1D
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![BU of 1z1d by Molmil](/molmil-images/mine/1z1d) | Structural Model for the interaction between RPA32 C-terminal domain and SV40 T antigen origin binding domain. | 分子名称: | Large T antigen, Replication protein A 32 kDa subunit | 著者 | Arunkumar, A.I, Klimovich, V, Jiang, X, Ott, R.D, Mizoue, L, Fanning, E, Chazin, W.J. | 登録日 | 2005-03-03 | 公開日 | 2005-05-17 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome. Nat.Struct.Mol.Biol., 12, 2005
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1IDW
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![BU of 1idw by Molmil](/molmil-images/mine/1idw) | STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[CL]U IN PRESENCE OF RH(NH3)6+++ | 分子名称: | 5'-R(*GP*CP*UP*UP*CP*GP*GP*C)-D(P*(UCL))-3', CHLORIDE ION, RHODIUM HEXAMINE ION | 著者 | Cruse, W, Saludjian, P, Neuman, A, Prange, T. | 登録日 | 2001-04-05 | 公開日 | 2001-04-12 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues Acta Crystallogr.,Sect.D, 57, 2001
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1IHA
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![BU of 1iha by Molmil](/molmil-images/mine/1iha) | Structure of the Hybrid RNA/DNA R-GCUUCGGC-D[BR]U in Presence of RH(NH3)6+++ | 分子名称: | 5'-R(*GP*CP*UP*UP*CP*GP*GP*C)-D(P*(BRU))-3', CHLORIDE ION, RHODIUM HEXAMINE ION | 著者 | Cruse, W.B, Saludjian, P, Neuman, A, Prange, T. | 登録日 | 2001-04-19 | 公開日 | 2001-05-07 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues. Acta Crystallogr.,Sect.D, 57, 2001
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8SYJ
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![BU of 8syj by Molmil](/molmil-images/mine/8syj) | Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Iodide crystal form) | 分子名称: | GLYCEROL, IODIDE ION, SULFATE ION, ... | 著者 | Eckenroth, B.E, Gardner, A.F, Doublie, S. | 登録日 | 2023-05-25 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
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1U0D
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![BU of 1u0d by Molmil](/molmil-images/mine/1u0d) | Y33H Mutant of Homing endonuclease I-CreI | 分子名称: | 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*CP*GP*C)-3', 5'-D(*GP*CP*GP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', DNA endonuclease I-CreI | 著者 | Sussman, D, Chadsey, M, Fauce, S, Engel, A, Bruett, A, Monnat, R, Stoddard, B.L, Seligman, L.M. | 登録日 | 2004-07-13 | 公開日 | 2004-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Isolation and characterization of new homing endonuclease specificities at individual target site positions. J.Mol.Biol., 342, 2004
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4CSA
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![BU of 4csa by Molmil](/molmil-images/mine/4csa) | Crystal structure of the asymmetric human metapneumovirus M2-1 tetramer bound to a DNA 4-mer | 分子名称: | 5'-D(*AP*GP*TP*TP*AP)-3', GLYCEROL, M2-1, ... | 著者 | Leyrat, C, Renner, M, Harlos, K, Grimes, J.M. | 登録日 | 2014-03-05 | 公開日 | 2014-05-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Drastic Changes in Conformational Dynamics of the Antiterminator M2-1 Regulate Transcription Efficiency in Pneumovirinae. Elife, 3, 2014
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7EDB
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8T4N
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5U6K
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7ZUR
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![BU of 7zur by Molmil](/molmil-images/mine/7zur) | Four carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder | 分子名称: | 16,17-dimethoxy-21-(4-pyridin-4-ylbutyl)-5,7-dioxa-13$l^{4}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15,17,19-octaene, DNA TAGGGTTAGGGT, POTASSIUM ION | 著者 | Bazzicalupi, C, Ferraroni, M, Gratteri, P, Papi, F. | 登録日 | 2022-05-13 | 公開日 | 2022-12-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis. Int J Mol Sci, 23, 2022
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1AL0
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![BU of 1al0 by Molmil](/molmil-images/mine/1al0) | PROCAPSID OF BACTERIOPHAGE PHIX174 | 分子名称: | CAPSID PROTEIN GPF, SCAFFOLDING PROTEIN GPB, SCAFFOLDING PROTEIN GPD, ... | 著者 | Rossmann, M.G, Dokland, T. | 登録日 | 1997-06-06 | 公開日 | 1998-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of a viral procapsid with molecular scaffolding. Nature, 389, 1997
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8AAD
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![BU of 8aad by Molmil](/molmil-images/mine/8aad) | Two carbons pendant pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder | 分子名称: | 16,17-dimethoxy-21-(2-pyridin-4-ylethyl)-5,7-dioxa-13$l^{4}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(13),2,4(8),9,14,16,18,20-octaene, DNA TAGGGTTAGGGT, POTASSIUM ION | 著者 | Ferraroni, M, Bazzicalupi, C, Gratteri, P, Papi, F. | 登録日 | 2022-07-01 | 公開日 | 2022-12-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis. Int J Mol Sci, 23, 2022
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7E8I
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![BU of 7e8i by Molmil](/molmil-images/mine/7e8i) | Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin | 分子名称: | BRCA1-associated RING domain protein 1, DNA (145-MER), Histone H2A, ... | 著者 | Dai, Y, Dai, L, Zhou, Z. | 登録日 | 2021-03-01 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin. Mol.Cell, 81, 2021
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3N5N
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1NHH
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![BU of 1nhh by Molmil](/molmil-images/mine/1nhh) | Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium | 分子名称: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | 著者 | Hu, X, Machius, M, Yang, W. | 登録日 | 2002-12-19 | 公開日 | 2003-06-10 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Monovalent cation dependence and preference of GHKL ATPases and kinases FEBS Lett., 544, 2003
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5HGK
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5HGM
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3UVF
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![BU of 3uvf by Molmil](/molmil-images/mine/3uvf) | Expanding LAGALIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Intron-encoded DNA endonuclease I-HjeMI, ... | 著者 | Jacoby, K, Metzger, M, Shen, B, Jarjour, J, Stoddard, B, Scharenberg, A. | 登録日 | 2011-11-29 | 公開日 | 2012-02-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Res., 40, 2012
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