7C7O
Crystal structure of E.coli DNA gyrase B in complex with 6-fluoro-8-(methylamino)-2-oxo-1,2-dihydroquinoline derivative
Summary for 7C7O
Entry DOI | 10.2210/pdb7c7o/pdb |
Descriptor | DNA gyrase subunit B, 4-[[4-(3-azanylpropylamino)-6-fluoranyl-8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid (3 entities in total) |
Functional Keywords | inhibitor, complex, topoisomerase, escherichia coli, isomerase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 24618.61 |
Authors | Kamitani, M.,Mima, M.,Takeuchi, T.,Ushiyama, F. (deposition date: 2020-05-26, release date: 2020-10-14, Last modification date: 2023-11-29) |
Primary citation | Ushiyama, F.,Amada, H.,Mihara, Y.,Takeuchi, T.,Tanaka-Yamamoto, N.,Mima, M.,Kamitani, M.,Wada, R.,Tamura, Y.,Endo, M.,Masuko, A.,Takata, I.,Hitaka, K.,Sugiyama, H.,Ohtake, N. Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg.Med.Chem., 28:115776-115776, 2020 Cited by PubMed: 33032189DOI: 10.1016/j.bmc.2020.115776 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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