2NZU
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![BU of 2nzu by Molmil](/molmil-images/mine/2nzu) | Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors G6P and FBP | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, Catabolite control protein, Phosphocarrier protein HPr, ... | 著者 | Schumacher, M.A, Hillen, W, Brennan, R.G. | 登録日 | 2006-11-25 | 公開日 | 2007-05-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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4AQ2
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![BU of 4aq2 by Molmil](/molmil-images/mine/4aq2) | resting state of homogentisate 1,2-dioxygenase | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, HOMOGENTISATE 1,2-DIOXYGENASE | 著者 | Jeoung, J.-H, Lin, T.-Y, Bommer, M, Dobbek, H. | 登録日 | 2012-04-12 | 公開日 | 2013-04-24 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Visualizing the Substrate-, Superoxo-, Alkylperoxo-, and Product-Bound States at the Nonheme Fe(II) Site of Homogentisate Dioxygenase. Proc.Natl.Acad.Sci.USA, 110, 2013
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4AQ6
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![BU of 4aq6 by Molmil](/molmil-images/mine/4aq6) | substrate bound homogentisate 1,2-dioxygenase | 分子名称: | 2-(3,6-DIHYDROXYPHENYL)ACETIC ACID, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, ... | 著者 | Jeoung, J.-H, Lin, T.-Y, Bommer, M, Dobbek, H. | 登録日 | 2012-04-12 | 公開日 | 2013-04-24 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Visualizing the Substrate-, Superoxo-, Alkylperoxo- and Product-Bound States at the Non-Heme Fe(II) Site of Homogentisate Dioxygenase Proc.Natl.Acad.Sci.USA, 110, 2013
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3HRY
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5H58
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![BU of 5h58 by Molmil](/molmil-images/mine/5h58) | Structural and dynamics studies of the TetR family protein, CprB from Streptomyces coelicolor in complex with its biological operator sequence | 分子名称: | CprB, DNA (5'-D(*AP*GP*GP*C*AP*GP*GP*CP*GP*GP*CP*AP*CP*GP*GP*TP*CP*TP*GP*TP*TP*GP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*A*CP*TP*CP*AP*AP*CP*AP*GP*AP*CP*CP*GP*TP*GP*CP*CP*GP*CP*CP*TP*GP*CP*CP*T)-3') | 著者 | Bhukya, H, Jana, A.K, Sengupta, N, Anand, R. | 登録日 | 2016-11-04 | 公開日 | 2017-05-03 | 最終更新日 | 2017-05-31 | 実験手法 | X-RAY DIFFRACTION (3.991 Å) | 主引用文献 | Structural and dynamics studies of the TetR family protein, CprB from Streptomyces coelicolor in complex with its biological operator sequence J. Struct. Biol., 198, 2017
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2NZV
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![BU of 2nzv by Molmil](/molmil-images/mine/2nzv) | Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors G6P and FBP | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, Catabolite control protein, Phosphocarrier protein HPr, ... | 著者 | Schumacher, M.A, Hillen, W, Brennan, R.G. | 登録日 | 2006-11-25 | 公開日 | 2007-05-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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3F8L
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![BU of 3f8l by Molmil](/molmil-images/mine/3f8l) | Crystal Structure of the Effector Domain of PhnF from Mycobacterium smegmatis | 分子名称: | GLYCEROL, HTH-type transcriptional repressor phnF, SULFATE ION | 著者 | Busby, J.N, Gebhard, S, Cook, G.M, Baker, E.N, Lott, S.J, Money, V.A. | 登録日 | 2008-11-12 | 公開日 | 2009-11-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of PhnF, a GntR-family transcription regulator in Mycobacterium smegmatis To be Published
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3FBR
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![BU of 3fbr by Molmil](/molmil-images/mine/3fbr) | structure of HipA-amppnp-peptide | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase toxin HipA, peptide of EF-Tu | 著者 | Schumacher, M.A. | 登録日 | 2008-11-19 | 公開日 | 2009-02-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science, 323, 2009
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7VJQ
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![BU of 7vjq by Molmil](/molmil-images/mine/7vjq) | Pectobacterium phage ZF40 apo-aca2 complexed with 26bp DNA substrate | 分子名称: | CHLORIDE ION, DNA (27-MER), GLYCEROL, ... | 著者 | Liu, Y.H, Zhang, L.S, Wu, B.X, Huang, H.D. | 登録日 | 2021-09-28 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2. J.Biol.Chem., 297, 2021
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7VJO
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![BU of 7vjo by Molmil](/molmil-images/mine/7vjo) | Pectobacterium phage ZF40 apo-Aca2 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, anti-CRISPR-associated protein Aca2 | 著者 | Liu, Y.H, Zhang, L.S, Wu, B.X, Huang, H.D. | 登録日 | 2021-09-28 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2. J.Biol.Chem., 297, 2021
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7VJN
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7VJM
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![BU of 7vjm by Molmil](/molmil-images/mine/7vjm) | Aca1 in complex with 19bp palindromic DNA substrate | 分子名称: | DNA (5'-D(*AP*TP*TP*AP*GP*GP*CP*AP*CP*AP*TP*TP*GP*TP*GP*CP*CP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*GP*GP*CP*AP*CP*AP*AP*TP*GP*TP*GP*CP*CP*TP*AP*A)-3'), anti-CRISPR-associated protein Aca1 | 著者 | Liu, Y.H, Zhang, L.S, Wu, B.X, Huang, H.D. | 登録日 | 2021-09-28 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2. J.Biol.Chem., 297, 2021
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1I2A
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1QNL
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4YO2
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![BU of 4yo2 by Molmil](/molmil-images/mine/4yo2) | Structure of E2F8, an atypical member of E2F family of transcription factors | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*CP*CP*CP*GP*CP*CP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*GP*GP*CP*GP*GP*GP*AP*AP*AP*A)-3'), Transcription factor E2F8 | 著者 | Morgunova, E, Yin, Y, Jolma, A, Dave, K, Schmierer, B, Popov, A, Eremina, N, Nilsson, L, Taipale, J. | 登録日 | 2015-03-11 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.073 Å) | 主引用文献 | Structural insights into the DNA-binding specificity of E2F family transcription factors. Nat Commun, 6, 2015
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8YM7
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![BU of 8ym7 by Molmil](/molmil-images/mine/8ym7) | Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45 | 分子名称: | 4-[5-(4-azanylpiperidin-1-yl)-8-(4-methylphenyl)pyrido[3,4-b]pyrazin-7-yl]-2-fluoranyl-benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... | 著者 | Zhiyan, D, Danyan, C, Hong, J, Tongchao, L, Bing, X. | 登録日 | 2024-03-08 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Discovery of Novel LSD1 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease To Be Published
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9FWG
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![BU of 9fwg by Molmil](/molmil-images/mine/9fwg) | LSD1/CoREST bound to bomedemstat | 分子名称: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | 著者 | Speranzini, V, Mattevi, A. | 登録日 | 2024-06-30 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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1A4X
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![BU of 1a4x by Molmil](/molmil-images/mine/1a4x) | PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, HEXAMERIC FORM | 分子名称: | PYRIMIDINE OPERON REGULATORY PROTEIN PYRR, SULFATE ION | 著者 | Tomchick, D.R, Turner, R.J, Switzer, R.W, Smith, J.L. | 登録日 | 1998-02-08 | 公開日 | 1998-08-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase. Structure, 6, 1998
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8FY2
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![BU of 8fy2 by Molmil](/molmil-images/mine/8fy2) | E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY0
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![BU of 8fy0 by Molmil](/molmil-images/mine/8fy0) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | 分子名称: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | 著者 | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY1
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![BU of 8fy1 by Molmil](/molmil-images/mine/8fy1) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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6TWJ
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6TWM
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![BU of 6twm by Molmil](/molmil-images/mine/6twm) | Product bound structure of the Ectoine utilization protein EutE (DoeB) from Ruegeria pomeroyi | 分子名称: | 2,4-DIAMINOBUTYRIC ACID, ACETATE ION, N-acetyl-L-2,4-diaminobutyric acid deacetylase, ... | 著者 | Mais, C.-N, Altegoer, F, Bange, G. | 登録日 | 2020-01-13 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase-deacetylase complex. J.Biol.Chem., 295, 2020
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6U4Y
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6TWK
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![BU of 6twk by Molmil](/molmil-images/mine/6twk) | Substrate bound structure of the Ectoine utilization protein EutD (DoeA) from Halomonas elongata | 分子名称: | (2~{R})-4-azanyl-2-[[(1~{S})-1-oxidanylethyl]amino]butanoic acid, (4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Ectoine hydrolase DoeA | 著者 | Mais, C.-N, Altegoer, F, Bange, G. | 登録日 | 2020-01-13 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase-deacetylase complex. J.Biol.Chem., 295, 2020
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