PDB: 1811 件ウェブページステータス検索Chemie searchBIRD

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2Q6J	Crystal Structure of Estrogen Receptor alpha Complexed to a B-N Substituted Ligand 分子名称: 4-[(DIMESITYLBORYL)(2,2,2-TRIFLUOROETHYL)AMINO]PHENOL, Estrogen receptor, GRIP peptide 著者 Zhou, H, Nettles, K.W, Bruning, J.B, Kim, Y, Joachimiak, A, Sharma, S, Carlson, K.E, Stossi, F, Katzenellenbogen, B.S, Greene, G.L, Katzenellenbogen, J.A. 登録日 2007-06-05 公開日 2007-06-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands Chem.Biol., 14, 2007
6MD0	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Oleic Acid 分子名称: OLEIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2018-09-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
2QZO	Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916 分子名称: 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol, Estrogen receptor, Nuclear receptor coactivator 2 著者 Bruning, J.B, Gil, G, Nowak, J, Katzenellenbogen, J, Nettles, K.W. 登録日 2007-08-16 公開日 2008-08-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Coupling of receptor conformation and ligand orientation determine graded activity. Nat.Chem.Biol., 6, 2010
2QTU	Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand 分子名称: (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol, Estrogen receptor beta 著者 Richardson, T.I, Dodge, J.A, Wang, Y, Durbin, J.D, Krishnan, V, Norman, B.H. 登録日 2007-08-02 公開日 2007-10-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies. Bioorg.Med.Chem.Lett., 17, 2007
2QMV	High Resolution Structure of Peroxisone Proliferation-Activated Receptor gamma and Characterisation of its Interaction with the Co-activator Transcriptional Intermediary Factor 2 分子名称: Peroxisome proliferator-activated receptor gamma 著者 Hartl, R, Riepl, H, Kauschke, S, Kalbitzer, H.R, Maurer, T. 登録日 2007-07-17 公開日 2008-09-02 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 High Resolution Structure of Peroxisone Proliferation-Activated Receptor gamma and Characterisation of its Interaction with the Co-activator Transcriptional Intermediary Factor 2 To be Published
6LX8	X-ray structure of human PPARalpha ligand binding domain-oleic acid co-crystals obtained by delipidation and cross-seeding 分子名称: GLYCEROL, OLEIC ACID, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
2OM9	Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma 分子名称: (6AR,10AR)-3-(1,1-DIMETHYLHEPTYL)-1-HYDROXY-6,6-DIMETHYL-6A,7,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMENE-9-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Ambrosio, A.L.B, Garratt, R.C. 登録日 2007-01-21 公開日 2007-04-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor gamma J.Biol.Chem., 282, 2007
2OVM	Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor NCoR 分子名称: 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, NCoR, Progesterone receptor 著者 Madauss, K.P, Deng, S.-J, Short, S.A, Stewart, E.L, Williams, S.P. 登録日 2007-02-14 公開日 2007-03-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. Mol.Endocrinol., 21, 2007
2QGW	Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with a Chloro-Indazole Compound 分子名称: 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nettles, K.W, Bruning, J.B, Nowak, J, Sharma, S.K, Hahm, J.B, Shi, Y, Kulp, K, Hochberg, R.B, Zhou, H, Katzenellenbogen, J.A, Katzenellenbogen, B.S, Kim, Y, Joachmiak, A, Greene, G.L. 登録日 2007-06-29 公開日 2008-03-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nat.Chem.Biol., 4, 2008
6LOC	Crystal structure of RORgammat with ligand C46D bound 分子名称: 6-cyclobutyloxy-9-ethyl-~{N}-[(4-ethylsulfonylphenyl)methyl]carbazole-3-carboxamide, Nuclear receptor ROR-gamma 著者 Feng, Y, Shijie, C. 登録日 2020-01-04 公開日 2021-01-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.20014858 Å) 主引用文献 Crystal structure of RORgammat with ligand C46D bound To Be Published
6LXA	X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding 分子名称: 5,8,11,14,17-EICOSAPENTAENOIC ACID, GLYCEROL, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6MD1	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Oleic acid 分子名称: 2-chloro-5-nitro-N-phenylbenzamide, OLEIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2018-09-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
6LOA	Crystal structure of RORgammat with ligand C46D bound 分子名称: 9-ethyl-~{N}-[(4-ethylsulfonylphenyl)methyl]-6-propan-2-yloxy-carbazole-3-carboxamide, Nuclear receptor ROR-gamma 著者 Feng, Y, Shijie, C. 登録日 2020-01-04 公開日 2021-01-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.50003314 Å) 主引用文献 Crystal structure of RORgammat with ligand C46D bound To Be Published
6LX5	X-ray structure of human PPARalpha ligand binding domain-ciprofibrate co-crystals obtained by delipidation and co-crystallization 分子名称: 2-{4-[(1S)-2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6MCZ	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Arachidonic Acid 分子名称: ARACHIDONIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2018-09-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
6LX6	X-ray structure of human PPARalpha ligand binding domain-palmitic acid co-crystals obtained by delipidation and cross-seeding 分子名称: GLYCEROL, PALMITIC ACID, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6LXB	X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by soaking 分子名称: (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Honda, A, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
2V7C	Crystal Structure of Rev-Erb beta 分子名称: ORPHAN NUCLEAR RECEPTOR NR1D2 著者 Woo, E.-J, Jeong, D.G, Lim, M.-Y, Kim, S.J, Ryu, S.E. 登録日 2007-07-29 公開日 2007-10-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Insight Into the Constitutive Repression Function of the Nuclear Receptor Rev-Erbbeta J.Mol.Biol., 373, 2007
2QW4	Human NR4A1 ligand-binding domain 分子名称: Orphan nuclear receptor NR4A1 著者 Min, J.R, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2007-08-09 公開日 2007-08-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Human Nr4A1 Ligand-Binding Domain To be Published
2QR9	Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with an Oxabicyclic Derivative Compound 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 著者 Nettles, K.W, Bruning, J.B. 登録日 2007-07-27 公開日 2008-03-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nat.Chem.Biol., 4, 2008
6LN4	Estrogen-related receptor beta(ERR2) in complex with PGC1a-2a 分子名称: 10-mer from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Steroid hormone receptor ERR2 著者 Yao, B.Q, Li, Y. 登録日 2019-12-28 公開日 2020-10-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta. J.Mol.Biol., 432, 2020
6LOB	Crystal structure of RORgammat with ligand C46D bound 分子名称: 9-ethyl-~{N}-[(4-ethylsulfonylphenyl)methyl]carbazole-3-carboxamide, Nuclear receptor ROR-gamma 著者 Feng, Y, Shijie, C. 登録日 2020-01-04 公開日 2021-01-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.40006661 Å) 主引用文献 Crystal structure of RORgammat with ligand C46D bound To Be Published
6LX9	X-ray structure of human PPARalpha ligand binding domain-arachidonic acid co-crystals obtained by delipidation and cross-seeding 分子名称: ARACHIDONIC ACID, GLYCEROL, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6MD4	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Rosiglitazone and Oleic acid 分子名称: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), OLEIC ACID, ... 著者 Shang, J, Kojetin, D.J. 登録日 2018-09-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
2REW	Crystal Structure of PPARalpha ligand binding domain with BMS-631707 分子名称: (2S,3S)-1-(4-METHOXYPHENYL)-3-(3-(2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY)BENZYL)-4-OXOAZETIDINE-2-CARBOXYLIC ACID, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE, Peroxisome proliferator-activated receptor alpha 著者 Muckelbauer, J. 登録日 2007-09-27 公開日 2007-11-27 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Discovery of Azetidinone Acids as Conformationally-Constrained Dual (alpha/gamma) PPAR Activators To be Published

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