2QR9
Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with an Oxabicyclic Derivative Compound
Summary for 2QR9
Entry DOI | 10.2210/pdb2qr9/pdb |
Related | 2QSE 2QXM |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, receptor, steroid-binding, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus : Q8BN74 |
Total number of polymer chains | 4 |
Total formula weight | 62721.70 |
Authors | Nettles, K.W.,Bruning, J.B. (deposition date: 2007-07-27, release date: 2008-03-18, Last modification date: 2023-08-30) |
Primary citation | Nettles, K.W.,Bruning, J.B.,Gil, G.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L. NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nat.Chem.Biol., 4:241-247, 2008 Cited by PubMed: 18344977DOI: 10.1038/nchembio.76 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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