6LXB

X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by soaking

Summary for 6LXB

Entry DOI	10.2210/pdb6lxb/pdb
Descriptor	Peroxisome proliferator-activated receptor alpha, (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid (3 entities in total)
Functional Keywords	nuclear receptor, protein-ligand complex, ppar, transcription
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	31295.62
Authors	Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Oyama, T.,Ishii, I. (deposition date: 2020-02-10, release date: 2020-11-11, Last modification date: 2023-11-29)
Primary citation	Kamata, S.,Oyama, T.,Saito, K.,Honda, A.,Yamamoto, Y.,Suda, K.,Ishikawa, R.,Itoh, T.,Watanabe, Y.,Shibata, T.,Uchida, K.,Suematsu, M.,Ishii, I. PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23:101727-101727, 2020 Cited by PubMed: 33205029 DOI: 10.1016/j.isci.2020.101727 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation