2REW

Crystal Structure of PPARalpha ligand binding domain with BMS-631707

Summary for 2REW

• Entry DOI: 10.2210/pdb2rew/pdb
• Descriptor: Peroxisome proliferator-activated receptor alpha, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE, (2S,3S)-1-(4-METHOXYPHENYL)-3-(3-(2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY)BENZYL)-4-OXOAZETIDINE-2-CARBOXYLIC ACID, ... (4 entities in total)
• Functional Keywords: alpha helical, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q07869
• Total number of polymer chains: 1
• Total formula weight: 32691.05

Authors

Muckelbauer, J. (deposition date: 2007-09-27, release date: 2007-11-27, Last modification date: 2024-04-03)

• Primary citation: Wang, W.,Devasthale, P.,Farrelly, D.,Gu, L.,Peters, A.,Harrity, T.,Cap, M.,Chu, C.,Kunselman, L.,Morgan, N.,Ponticiello, R.,Zebo, R.,Zhang, L.,Locke, K.,Lippy, J.,O'Malley, K.,Hosagrahara, V.,Zhang, L.,Kadiyala, P.,Chang, C.Y.,Muckelbauer, J.,Zahler, R.,Hariharan, N.,Ryono, D.,Cheng, P.T.W.; Discovery of Azetidinone Acids as Conformationally-Constrained Dual (alpha/gamma) PPAR Activators; To be Published,

Experimental method

X-RAY DIFFRACTION (2.35 Å)