PDB: 179 件ウェブページステータス検索Chemie searchBIRD

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5DVY	2.95 Angstrom Crystal Structure of the Dimeric Form of Penicillin Binding Protein 2 Prime from Enterococcus faecium 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Penicillin binding protein 2 prime, SULFATE ION 著者 Minasov, G, Wawrzak, Z, Shuvalova, L, Dubrovska, I, Flores, K, Filippova, E, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2015-09-21 公開日 2015-10-07 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 2.95 Angstrom Crystal Structure of the Dimeric Form of Penicillin Binding Protein 2 Prime from Enterococcus faecium. To Be Published
5DF7	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH AZLOCILLIN 分子名称: (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, Cell division protein, ... 著者 Ren, J, Nettleship, J.E, Males, A, Stuart, D.I, Owens, R.J. 登録日 2015-08-26 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms. Febs Lett., 590, 2016
5DF8	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CEFOPERAZONE 分子名称: (2R,4R,5R)-2-[(1R)-1-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methyl-1,3-thiazinane-4-carboxylic acid, CHLORIDE ION, Cell division protein, ... 著者 Ren, J, Nettleship, J.E, Males, A, Stuart, D.I, Owens, R.J. 登録日 2015-08-26 公開日 2016-01-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms. Febs Lett., 590, 2016
5DF9	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 IN COMPLEX WITH DEACYLATED PRODUCT OF CEFOPERAZONE 分子名称: (2R,5R)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-methyl-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Cell division protein, GLYCEROL, ... 著者 Ren, J, Nettleship, J.E, Males, A, Stuart, D.I, Owens, R.J. 登録日 2015-08-26 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms. Febs Lett., 590, 2016
4YE5	The crystal structure of a peptidoglycan synthetase from Bifidobacterium adolescentis ATCC 15703 分子名称: ACETATE ION, GLYCEROL, Peptidoglycan synthetase penicillin-binding protein 3 著者 Cuff, M, Tan, K, Joachimiak, G, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2015-02-23 公開日 2015-03-18 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 The crystal structure of a peptidoglycan synthetase from Bifidobacterium adolescentis ATCC 15703 To Be Published
4WEJ	Crystal structure of Pseudomonas aeruginosa PBP3 with a R4 substituted allyl monocarbam 分子名称: (3R,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-4-formyl-1-[({3-[(5R)-5-hydroxy-4-oxo-4,5-dihydropyridin-2-yl]-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-10,10-dimethyl-1,6-dioxo-3-(prop-2-en-1-yl)-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.045 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
4WEL	Crystal structure of Pseudomonas aeruginosa PBP3 with SMC-3176 分子名称: (3S,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-4-formyl-1-[({3-(5-hydroxy-4-oxo-3,4-dihydropyridin-2-yl)-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-3,10,10-trimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
4WEK	Crystal structure of Pseudomonas aeruginosa PBP3 with a R4 substituted vinyl monocarbam 分子名称: (3S,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-3-ethenyl-4-formyl-1-[({3-(5-hydroxy-4-oxo-3,4-dihydropyridin-2-yl)-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
4OVD	Crystal structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum DSM 20469 分子名称: CALCIUM ION, Peptidoglycan glycosyltransferase 著者 Filippova, E.V, Wawrzak, Z, Kiryukhina, O, Babnigg, G, Clancy, S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) 登録日 2014-02-21 公開日 2014-03-12 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum DSM 20469 To be Published
4CPK	Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, Penicillin binding protein 2 prime, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2014-02-07 公開日 2014-09-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
4CJN	Crystal structure of PBP2a from MRSA in complex with quinazolinone ligand 分子名称: (E)-3-(2-(4-cyanostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid, CADMIUM ION, CHLORIDE ION, ... 著者 Bouley, R, Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2013-12-21 公開日 2015-02-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.947 Å) 主引用文献 Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-Cyanostyryl)Quinazolin-4(3H)-One. J.Am.Chem.Soc., 137, 2015
4L0L	Crystal structure of P.aeruginosa PBP3 in complex with compound 4 分子名称: (6R,7S,10Z)-10-(2-amino-1,3-thiazol-4-yl)-1-(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)-7-formyl-13,13-dimethyl-3,9-dioxo-6-(sulfoamino)-12-oxa-2,4,8,11-tetraazatetradec-10-en-14-oic acid, Penicillin-binding protein 3 著者 Han, S, Marr, E.S. 登録日 2013-05-31 公開日 2013-08-21 最終更新日 2014-01-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Pyridone-conjugated monobactam antibiotics with gram-negative activity. J.Med.Chem., 56, 2013
4KQQ	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid 分子名称: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
4KQR	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid 分子名称: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
4KQO	Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with piperacillin 分子名称: CHLORIDE ION, GLYCEROL, IMIDAZOLE, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
4BL3	Crystal structure of PBP2a clinical mutant N146K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, PENICILLIN BINDING PROTEIN 2 PRIME, ... 著者 Otero, L.H, Rojas-Altuve, A, Carrasco-Lopez, C, Hermoso, J.A. 登録日 2013-04-30 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
4BL2	Crystal structure of PBP2a clinical mutant E150K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, PENICILLIN BINDING PROTEIN 2 PRIME 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2013-04-30 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
3ZG5	Crystal structure of PBP2a from MRSA in complex with peptidoglycan analogue at allosteric 分子名称: CADMIUM ION, CHLORIDE ION, PEPTIDOGLYCAN ANALOGUE, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2012-12-14 公開日 2013-10-09 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110, 2013
3ZG0	Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization 分子名称: CADMIUM ION, CHLORIDE ION, Ceftaroline, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2012-12-13 公開日 2013-10-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110, 2013
3ZFZ	Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by soaking 分子名称: CADMIUM ION, CHLORIDE ION, Ceftaroline, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2012-12-13 公開日 2013-10-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110, 2013
4FSF	Crystal structure of Pseudomonas aeruginosa PBP3 complexed with compound 14 分子名称: (4R,5S,8Z)-8-(2-amino-1,3-thiazol-4-yl)-1-[3-(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)-1,2-oxazol-5-yl]-5-formyl-11,11-dimethyl-1,7-dioxo-4-(sulfoamino)-10-oxa-2,6,9-triazadodec-8-en-12-oic acid, Penicillin-binding protein 3 著者 Han, S. 登録日 2012-06-27 公開日 2012-10-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections. Bioorg.Med.Chem.Lett., 22, 2012
3VSK	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the apo form. 分子名称: Penicillin-binding protein 3 著者 Yoshida, H, Tame, J.R, Park, S.Y. 登録日 2012-04-25 公開日 2012-10-31 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
3VSL	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the cefotaxime bound form. 分子名称: CEFOTAXIME, C3' cleaved, open, ... 著者 Yoshida, H, Tame, J.R, Park, S.Y. 登録日 2012-04-25 公開日 2012-10-31 最終更新日 2017-03-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
4DKI	Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole 分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, BICARBONATE ION, CADMIUM ION, ... 著者 Lovering, A.L, Gretes, M.C, Strynadka, N.C.J. 登録日 2012-02-03 公開日 2012-08-01 最終更新日 2012-10-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole. J.Biol.Chem., 287, 2012
3UE3	Crystal structure of Acinetobacter baumanni PBP3 分子名称: Septum formation, penicillin binding protein 3, peptidoglycan synthetase 著者 Han, S. 登録日 2011-10-28 公開日 2011-12-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics J.Am.Chem.Soc., 133, 2011

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