4FSF

Crystal structure of Pseudomonas aeruginosa PBP3 complexed with compound 14

Summary for 4FSF

• Entry DOI: 10.2210/pdb4fsf/pdb
• Descriptor: Penicillin-binding protein 3, (4R,5S,8Z)-8-(2-amino-1,3-thiazol-4-yl)-1-[3-(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)-1,2-oxazol-5-yl]-5-formyl-11,11-dimethyl-1,7-dioxo-4-(sulfoamino)-10-oxa-2,6,9-triazadodec-8-en-12-oic acid (3 entities in total)
• Functional Keywords: penicillin binding protein, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 58813.81

Authors

Han, S. (deposition date: 2012-06-27, release date: 2012-10-17)

• Primary citation: Mitton-Fry, M.J.,Arcari, J.T.,Brown, M.F.,Casavant, J.M.,Finegan, S.M.,Flanagan, M.E.,Gao, H.,George, D.M.,Gerstenberger, B.S.,Han, S.,Hardink, J.R.,Harris, T.M.,Hoang, T.,Huband, M.D.,Irvine, R.,Lall, M.S.,Megan Lemmon, M.,Li, C.,Lin, J.,McCurdy, S.P.,Mueller, J.P.,Mullins, L.,Niosi, M.,Noe, M.C.,Pattavina, D.,Penzien, J.,Plummer, M.S.,Risley, H.,Schuff, B.P.,Shanmugasundaram, V.,Starr, J.T.,Sun, J.,Winton, J.,Young, J.A.; Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.; Bioorg.Med.Chem.Lett., 22:5989-5994, 2012; PubMed: 22892121; DOI: 10.1016/j.bmcl.2012.07.005

Experimental method

X-RAY DIFFRACTION (2.2 Å)