5DF9

CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 IN COMPLEX WITH DEACYLATED PRODUCT OF CEFOPERAZONE

Summary for 5DF9

• Entry DOI: 10.2210/pdb5df9/pdb
• Related: 5DF8
• Descriptor: Cell division protein, SULFATE ION, (2R,5R)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-methyl-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ... (5 entities in total)
• Functional Keywords: cefoperazone, beta-lactam antibiotics, acyl-enzyme complex, de-acylation, transferase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 61986.36

Authors

Ren, J.,Nettleship, J.E.,Males, A.,Stuart, D.I.,Owens, R.J. (deposition date: 2015-08-26, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Ren, J.,Nettleship, J.E.,Males, A.,Stuart, D.I.,Owens, R.J.; Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.; Febs Lett., 590:288-297, 2016; PubMed: 26823174; DOI: 10.1002/1873-3468.12054

Experimental method

X-RAY DIFFRACTION (2.7 Å)