4DKI

Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

Summary for 4DKI

• Entry DOI: 10.2210/pdb4dki/pdb
• Descriptor: Penicillin-binding protein 2', (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, BICARBONATE ION, ... (6 entities in total)
• Functional Keywords: enzyme, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 2
• Total formula weight: 149800.43

Authors

Lovering, A.L.,Gretes, M.C.,Strynadka, N.C.J. (deposition date: 2012-02-03, release date: 2012-08-01, Last modification date: 2012-10-03)

• Primary citation: Lovering, A.L.,Gretes, M.C.,Safadi, S.S.,Danel, F.,de Castro, L.,Page, M.G.,Strynadka, N.C.; Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole.; J.Biol.Chem., 287:32096-32102, 2012; PubMed: 22815485; DOI: 10.1074/jbc.M112.355644

Experimental method

X-RAY DIFFRACTION (2.9 Å)