PDB: 97310 件ウェブページステータス検索Chemie searchBIRD

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8YD7	Structure of FADD/Caspase-8/cFLIP death effector domain assembly 分子名称: CASP8 and FADD-like apoptosis regulator subunit p12, Caspase-8, FAS-associated death domain protein, ... 著者 Lin, S.-C, Yang, C.-Y. 登録日 2024-02-19 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun, 15, 2024
8SCD	Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate 分子名称: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, CHLORIDE ION, ... 著者 Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2023-04-05 公開日 2023-05-03 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
4IAD	Low temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphorylated peptide pSP20, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2016-09-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
9AZ7	Chloride Sites in Photoactive Yellow Protein 分子名称: 4'-HYDROXYCINNAMIC ACID, CHLORIDE ION, Photoactive yellow protein 著者 Dyda, F, Schotte, F, Anfinrud, P, Cho, H.S. 登録日 2024-03-10 公開日 2024-03-20 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Watching a signaling protein function: What has been learned over four decades of time-resolved studies of photoactive yellow protein. Struct Dyn., 11, 2024
4IAZ	Structure of cAMP dependent protein kinase A in complex with high Ba2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, BARIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-07 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
8XA9	Human MGME1 in complex with 5'-overhang DNA 分子名称: CALCIUM ION, DNA (11-MER), DNA (18-MER), ... 著者 Wu, C.C, Mao, E.Y.C. 登録日 2023-12-03 公開日 2024-03-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Structural basis of how MGME1 processes DNA 5' ends to maintain mitochondrial genome integrity. Nucleic Acids Res., 52, 2024
9AZ9	Chloride Sites in Photoactive Yellow Protein (Chloride-Free Reference Structure) 分子名称: 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein 著者 Dyda, F, Schotte, F, Anfinrud, P, Cho, H.S. 登録日 2024-03-10 公開日 2024-03-20 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Watching a signaling protein function: What has been learned over four decades of time-resolved studies of photoactive yellow protein. Struct Dyn., 11, 2024
8BAO	Dysgonamonadaceae bacterium CRISPR ancillary nuclease 2 分子名称: BROMIDE ION, Cyclic tetra-adenylate (cA4), DUF1887 family protein, ... 著者 Li, A.W.H, Doherty, A.J. 登録日 2022-10-11 公開日 2022-11-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Reverse transcriptases prime DNA synthesis. Nucleic Acids Res., 51, 2023
8S9M	DNA cytosine-N4 methyltransferase (residues 79-324) from the Bdelloid rotifer Adineta vaga 分子名称: 1,2-ETHANEDIOL, DNA cytosine-N4 methyltransferase, SINEFUNGIN 著者 Zhou, J, Horton, J.R, Cheng, X. 登録日 2023-03-29 公開日 2023-08-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J.Biol.Chem., 299, 2023
8S9N	DNA cytosine-N4 methyltransferase (residues 61-324) from the Bdelloid rotifer Adineta vaga - C2 crystal form 分子名称: 1,2-ETHANEDIOL, DNA cytosine-N4 methyltransferase, SINEFUNGIN 著者 Zhou, J, Horton, J.R, Cheng, X. 登録日 2023-03-29 公開日 2023-08-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J.Biol.Chem., 299, 2023
8B4A	Nativ complex of PqsE and RhlR with autoinducer C4-HSL 分子名称: 2-aminobenzoylacetyl-CoA thioesterase, FE (III) ION, N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide, ... 著者 Borgert, S.R, Blankenfeldt, W. 登録日 2022-09-20 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nat Commun, 13, 2022
8S9O	DNA cytosine-N4 methyltransferase (residues 61-324) from the Bdelloid rotifer Adineta vaga - P1 crystal form 分子名称: 1,2-ETHANEDIOL, DNA cytosine-N4 methyltransferase, SINEFUNGIN 著者 Zhou, J, Horton, J.R, Cheng, X. 登録日 2023-03-29 公開日 2023-08-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J.Biol.Chem., 299, 2023
8YJX	Crystal structure of penicillin-binding protein 2 (PBP2) from Campylobacter jejuni 分子名称: Penicillin-binding protein 2, ZINC ION 著者 Choi, H.J, Ki, D.W, Yoon, S.I. 登録日 2024-03-03 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural and biochemical analysis of penicillin-binding protein 2 from Campylobacter jejuni. Biochem.Biophys.Res.Commun., 710, 2024
8XN7	Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f 分子名称: 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 著者 Huang, W.X, Liu, R, Ding, K. 登録日 2023-12-29 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269, 2024
6GKJ	Translation initiation factor 4E in complex with trinucleotide mRNA 5' cap (m7GpppApG) 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, GLYCEROL 著者 Warminski, M, Nowak, E, Kowalska, J, Jemielity, J, Nowotny, M. 登録日 2018-05-21 公開日 2019-06-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.068 Å) 主引用文献 Translation initiation factor 4E in complex with trinucleotide mRNA 5' cap (m7GpppApG) To Be Published
5BUE	ERK2 complexed with N-benzylpyridone tetrahydroazaindazole 分子名称: 1-benzyl-4-[3-(pyridin-4-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1, NICKEL (II) ION 著者 Bellamacina, C.R, Shu, W, Bussiere, D.E, Bagdanoff, J.T. 登録日 2015-06-03 公開日 2015-07-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase. Bioorg.Med.Chem.Lett., 25, 2015
6TQK	Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, ... 著者 Stsiapanava, A, Xu, C, Carroni, M, Wu, B, Jovine, L. 登録日 2019-12-16 公開日 2020-11-04 最終更新日 2021-03-03 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Cryo-EM structure of native human uromodulin, a zona pellucida module polymer. Embo J., 39, 2020
5BUJ	ERK2 complexed with a N-H tetrahydroazaindazole 分子名称: 4-[3-(pyridin-4-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1 著者 Bellamacina, C.R, Shu, W, Bussiere, D.E, Bagdanoff, J.T. 登録日 2015-06-03 公開日 2015-07-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase. Bioorg.Med.Chem.Lett., 25, 2015
8BR9	Stapled peptide SP24 in complex with humanised RadA mutant HumRadA22 分子名称: 4,6-diethylpyrimidin-2-amine, ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility protein, ... 著者 Pantelejevs, T, Hyvonen, M. 登録日 2022-11-22 公開日 2023-03-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chem Sci, 14, 2023
5AX3	Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors. 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Mitogen-activated protein kinase 1, allosteric and ATP-competitive inhibitor 著者 Kinoshita, T, Sugiyama, H, Mori, Y, Takahashi, N, Tomonaga, A. 登録日 2015-07-14 公開日 2016-02-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.984 Å) 主引用文献 Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay Bioorg.Med.Chem.Lett., 26, 2016
3VJF	Crystal structure of de novo 4-helix bundle protein WA20 分子名称: POTASSIUM ION, WA20 著者 Arai, R, Kimura, A, Kobayashi, N, Matsuo, K, Sato, T, Wang, A.F, Platt, J.M, Bradley, L.H, Hecht, M.H. 登録日 2011-10-18 公開日 2012-03-28 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Domain-swapped dimeric structure of a stable and functional de novo four-helix bundle protein, WA20 J.Phys.Chem.B, 116, 2012
4NZ7	Steroid receptor RNA Activator (SRA) modification by the human Pseudouridine Synthase 1 (hPus1p): RNA binding, activity, and atomic model 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, TRIETHYLENE GLYCOL, tRNA pseudouridine synthase A, ... 著者 Huet, T, Thore, S. 登録日 2013-12-11 公開日 2014-05-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model Plos One, 9, 2014
4NZ6	Steroid receptor RNA Activator (SRA) modification by the human Pseudouridine Synthase 1 (hPus1p): RNA binding, activity, and atomic model 分子名称: 1,2-ETHANEDIOL, D-GLUTAMIC ACID, D-LYSINE, ... 著者 Huet, T, Thore, S. 登録日 2013-12-11 公開日 2014-05-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model Plos One, 9, 2014
4IAC	X-RAY structure of cAMP dependent protein kinase A in complex with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20 分子名称: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Peptide SP20, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2016-09-21 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IAI	X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CARBONATE ION, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013

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