8XN7
Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f
This is a non-PDB format compatible entry.
Summary for 8XN7
Entry DOI | 10.2210/pdb8xn7/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 67322.01 |
Authors | |
Primary citation | Qiu, X.,Liu, R.,Ling, H.,Zhou, Y.,Ren, X.,Zhou, F.,Zhang, J.,Huang, W.,Wang, Z.,Ding, K. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269:116310-116310, 2024 Cited by PubMed: 38479166DOI: 10.1016/j.ejmech.2024.116310 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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