8SCD

Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate

Summary for 8SCD

• Entry DOI: 10.2210/pdb8scd/pdb
• Related: 7S2I 7S2J 7S2K 7S2L 7S2M 7TQ1
• Descriptor: Sulfonamide resistance enzyme Sul3, 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, ... (8 entities in total)
• Functional Keywords: tim barrel, alpha beta protein, antibiotic resistance, sulfonamides, structural genomics, csgid, center for structural genomics of infectious diseases, csbid, center for structural biology of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase
• Biological source: uncultured bacterium
• Total number of polymer chains: 1
• Total formula weight: 29751.38

Authors

Stogios, P.J.,Venkatesan, M.,Michalska, K.,Mesa, N.,Di Leo, R.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2023-04-05, release date: 2023-05-03, Last modification date: 2023-07-19)

• Primary citation: Venkatesan, M.,Fruci, M.,Verellen, L.A.,Skarina, T.,Mesa, N.,Flick, R.,Pham, C.,Mahadevan, R.,Stogios, P.J.,Savchenko, A.; Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.; Nat Commun, 14:4031-4031, 2023; PubMed: 37419898; DOI: 10.1038/s41467-023-39778-7

Experimental method

X-RAY DIFFRACTION (2.06 Å)