5BUJ
ERK2 complexed with a N-H tetrahydroazaindazole
Summary for 5BUJ
| Entry DOI | 10.2210/pdb5buj/pdb |
| Related | 5BUE 5BUI |
| Descriptor | Mitogen-activated protein kinase 1, 4-[3-(pyridin-4-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]pyridin-2(1H)-one (3 entities in total) |
| Functional Keywords | erk2, mitogen-activated protein kinase 1, atp inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
| Total number of polymer chains | 1 |
| Total formula weight | 41760.95 |
| Authors | Bellamacina, C.R.,Shu, W.,Bussiere, D.E.,Bagdanoff, J.T. (deposition date: 2015-06-03, release date: 2015-07-15, Last modification date: 2024-03-06) |
| Primary citation | Bagdanoff, J.T.,Jain, R.,Han, W.,Poon, D.,Lee, P.S.,Bellamacina, C.,Lindvall, M. Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase. Bioorg.Med.Chem.Lett., 25:3626-3629, 2015 Cited by PubMed: 26144345DOI: 10.1016/j.bmcl.2015.06.063 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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